Academic Journal
Clostridium haemolyticum Infection: A Cause of Hemolytic Anemia in a Patient with Bone Marrow Necrosis
| العنوان: | Clostridium haemolyticum Infection: A Cause of Hemolytic Anemia in a Patient with Bone Marrow Necrosis |
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| المؤلفون: | Lagneaux, Anne, Sophie, Hénard, Sandrine, Diancourt, Laure, Stein, Emmanuelle, Perez, Pierre, Mathieu, Pierre, Alauzet, Corentine, Lozniewski, Alain |
| المساهمون: | Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre National de Référence des Bactéries Anaérobies et Botulisme - National Reference Center Anaerobic Bacteria and Botulism (CNR), Institut Pasteur Paris (IP)-Université Paris Cité (UPCité), Centre Hospitalier de Verdun Saint-Mihiel, Stress, Immunité, Pathogènes (SIMPA), Université de Lorraine (UL), This research received no external funding |
| المصدر: | ISSN: 2076-2607 ; Microorganisms ; https://pasteur.hal.science/pasteur-04146695 ; Microorganisms, 2021, 9 (8), pp.1568. ⟨10.3390/microorganisms9081568⟩. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Clostridium haemolyticum, bone marrow necrosis, hemolytic anemia, human infection, [SDV]Life Sciences [q-bio], [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology |
| الوصف: | International audience ; Clostridium haemolyticum is a sporulating Gram-positive anaerobic rod that is considered to be one of the most fastidious and oxygen-sensitive anaerobes. It is a well-known animal pathogen and the cause of bacillary hemoglobinuria primarily in cattle. To date, human infections caused by C. haemolyticum have been reported in three patients with malignant underlying diseases. We present herein the case of a 30-year-old obese woman with no significant past medical history who developed bacteremia caused by C. haemolyticum with massive intravascular hemolysis associated with bone marrow necrosis and acute renal failure. Because of subculture failure, the diagnosis was made on the basis of 16S rDNA sequencing and next-generation sequencing. The patient, who had been afebrile for 20 days after a 17-day-course of antibiotics, experienced a second bacteremic episode caused by C. haemolyticum. After having been successfully treated for 42 days with clindamycin and amoxicillin-clavulanic acid, the patient developed acute myeloid leukemia as a result of bone marrow regeneration. Although uncommon in humans, infections caused by C. haemolyticum are severe and should be considered in a febrile patient who has severe hemolytic anemia. This case also highlights the importance of using molecular techniques for the identification of this fastidious anaerobic organism. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34442646; pasteur-04146695; https://pasteur.hal.science/pasteur-04146695; https://pasteur.hal.science/pasteur-04146695/document; https://pasteur.hal.science/pasteur-04146695/file/microorganisms-09-01568.pdf; PUBMED: 34442646; PUBMEDCENTRAL: PMC8399981 |
| DOI: | 10.3390/microorganisms9081568 |
| الاتاحة: | https://pasteur.hal.science/pasteur-04146695 https://pasteur.hal.science/pasteur-04146695/document https://pasteur.hal.science/pasteur-04146695/file/microorganisms-09-01568.pdf https://doi.org/10.3390/microorganisms9081568 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.8C5E38E6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/microorganisms9081568 |
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