Academic Journal
Risk factors for severe outcomes for COVID-19 patients hospitalised in Switzerland during the first pandemic wave, February to August 2020: prospective observational cohort study
| العنوان: | Risk factors for severe outcomes for COVID-19 patients hospitalised in Switzerland during the first pandemic wave, February to August 2020: prospective observational cohort study |
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| المؤلفون: | Maximiano Sousa, Filipe, Roelens, Maroussia, Fricker, Brian, Thiabaud, Amaury, Iten, Anne, Cusini, Alexia, Flury, Domenica, Buettcher, Michael, Zukol, Franziska, Balmelli, Carlo, Zimmermann, Petra, Troillet, Nicolas, Vuichard-Gysin, Danielle, Schreiber, Peter W, Bernhard-Stirnemann, Sara, Tschudin-Sutter, Sarah, Nussbaumer-Ochsner, Yvonne, Sommerstein, Rami, Gaudenz, Roman, Marschall, Jonas, Senn, Laurence, Gardiol, Céline, Keiser, Olivia, Schüpbach, Gertraud, Wymann, Monica, Vidondo, Beatriz, Ch-Sur Study Group |
| المصدر: | Maximiano Sousa, Filipe; Roelens, Maroussia; Fricker, Brian; Thiabaud, Amaury; Iten, Anne; Cusini, Alexia; Flury, Domenica; Buettcher, Michael; Zukol, Franziska; Balmelli, Carlo; Zimmermann, Petra; Troillet, Nicolas; Vuichard-Gysin, Danielle; Schreiber, Peter W; Bernhard-Stirnemann, Sara; Tschudin-Sutter, Sarah; Nussbaumer-Ochsner, Yvonne; Sommerstein, Rami; Gaudenz, Roman; Marschall, Jonas; Senn, Laurence; Gardiol, Céline; Keiser, Olivia; Schüpbach, Gertraud; Wymann, Monica; Vidondo, Beatriz; Ch-Sur Study Group (2021). Risk factors for severe outcomes for COVID-19 patients hospitalised in Switzerland during the first pandemic wave, February to August 2020: prospective observational cohort study. Swiss Medical Weekly, 151:w20547. |
| بيانات النشر: | SMW supporting association |
| سنة النشر: | 2021 |
| المجموعة: | University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| مصطلحات موضوعية: | Clinic for Infectious Diseases, 610 Medicine & health |
| الوصف: | BACKGROUND As clinical signs of COVID-19 differ widely among individuals, from mild to severe, the definition of risk groups has important consequences for recommendations to the public, control measures and patient management, and needs to be reviewed regularly. AIM The aim of this study was to explore risk factors for in-hospital mortality and intensive care unit (ICU) admission for hospitalised COVID-19 patients during the first epidemic wave in Switzerland, as an example of a country that coped well during the first wave of the pandemic. METHODS This study included all (n = 3590) adult polymerase chain reaction (PCR)-confirmed hospitalised patients in 17 hospitals from the hospital-based surveillance of COVID-19 (CH-Sur) by 1 September 2020. We calculated univariable and multivariable (adjusted) (1) proportional hazards (Fine and Gray) survival regression models and (2) logistic regression models for in-hospital mortality and admission to ICU, to evaluate the most common comorbidities as potential risk factors. RESULTS AND DISCUSSION We found that old age was the strongest factor for in-hospital mortality after having adjusted for gender and the considered comorbidities (hazard ratio [HR] 2.46, 95% confidence interval [CI] 2.33−2.59 and HR 5.6 95% CI 5.23−6 for ages 65 and 80 years, respectively). In addition, male gender remained an important risk factor in the multivariable models (HR 1.47, 95% CI 1.41−1.53). Of all comorbidities, renal disease, oncological pathologies, chronic respiratory disease, cardiovascular disease (but not hypertension) and dementia were also risk factors for in-hospital mortality. With respect to ICU admission risk, the pattern was different, as patients with higher chances of survival might have been admitted more often to ICU. Male gender (OR 1.91, 95% CI 1.58−2.31), hypertension (OR 1.3, 95% CI 1.07−1.59) and age 55–79 years (OR 1.15, 95% CI 1.06−1.26) are risk factors for ICU admission. Patients aged 80+ years, as well as patients with dementia or with liver disease were ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1424-3997 |
| Relation: | https://www.zora.uzh.ch/id/eprint/210767/1/smw_2021_20547.pdf; info:pmid/34324698; urn:issn:1424-3997 |
| DOI: | 10.4414/smw.2021.20547 |
| الاتاحة: | https://www.zora.uzh.ch/id/eprint/210767/ https://www.zora.uzh.ch/id/eprint/210767/1/smw_2021_20547.pdf https://doi.org/10.4414/smw.2021.20547 |
| Rights: | info:eu-repo/semantics/openAccess ; Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) ; http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.8C5CCBAA |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14243997 |
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| DOI: | 10.4414/smw.2021.20547 |