Academic Journal
Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy
| العنوان: | Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy |
|---|---|
| المؤلفون: | Kalkan, H., Pagano, E., Paris, D., Panza, E., Cuozzo, M., Moriello, C., Piscitelli, F., Abolghasemi, A., Gazzerro, E., Silvestri, C., Capasso, R., Motta, A., Russo, R., Di Marzo, V., Iannotti, F.A. |
| بيانات النشر: | EMBO Press / Wiley |
| سنة النشر: | 2023 |
| المجموعة: | Max-Delbrueck-Center for Molecular Medicine, Berlin: MDC Repository |
| مصطلحات موضوعية: | Function and Dysfunction of the Nervous System, Topic 3: Integrative Biomedicine |
| الوصف: | Nothing is known about the potential implication of gut microbiota in skeletal muscle disorders. Here, we provide evidence that fecal microbiota composition along with circulating levels of short-chain fatty acids (SCFAs) and related metabolites are altered in the mdx mouse model of Duchenne muscular dystrophy (DMD) compared with healthy controls. Supplementation with sodium butyrate (NaB) in mdx mice rescued muscle strength and autophagy, and prevented inflammation associated with excessive endocannabinoid signaling at CB1 receptors to the same extent as deflazacort (DFZ), the standard palliative care for DMD. In LPS-stimulated C2C12 myoblasts, NaB reduces inflammation, promotes autophagy, and prevents dysregulation of microRNAs targeting the endocannabinoid CB1 receptor gene, in a manner depending on the activation of GPR109A and PPARγ receptors. In sum, we propose a novel disease-modifying approach in DMD that may have benefits also in other muscular dystrophies. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf; other |
| اللغة: | English |
| Relation: | http://edoc.mdc-berlin.de/23013/1/23013oa.pdf; http://edoc.mdc-berlin.de/23013/2/23013suppl.zip; Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy. Kalkan, H. and Pagano, E. and Paris, D. and Panza, E. and Cuozzo, M. and Moriello, C. and Piscitelli, F. and Abolghasemi, A. and Gazzerro, E. and Silvestri, C. and Capasso, R. and Motta, A. and Russo, R. and Di Marzo, V. and Iannotti, F.A. EMBO Molecular Medicine 15 (3): e16225. 8 March 2023 |
| DOI: | 10.15252/emmm.202216225 |
| الاتاحة: | http://edoc.mdc-berlin.de/23013/ https://edoc.mdc-berlin.de/23013/ http://edoc.mdc-berlin.de/23013/1/23013oa.pdf http://edoc.mdc-berlin.de/23013/2/23013suppl.zip https://doi.org/10.15252/emmm.202216225 |
| Rights: | cc_by_4 |
| رقم الانضمام: | edsbas.8C462C13 |
| قاعدة البيانات: | BASE |
| DOI: | 10.15252/emmm.202216225 |
|---|