Academic Journal
Model-based whole-brain perturbational landscape of neurodegenerative diseases
| العنوان: | Model-based whole-brain perturbational landscape of neurodegenerative diseases |
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| المؤلفون: | Perl, Yonatan Sanz, Fittipaldi, Sol, Campo, Cecilia Gonzalez, Moguilner, Sebastián, Cruzat, Josephine, Fraile-Vazquez, Matias E., Herzog, Rubén, Kringelbach, Morten L., Deco, Gustavo, Prado, Pavel, Ibanez, Agustin, Tagliazucchi, Enzo |
| المصدر: | Perl , Y S , Fittipaldi , S , Campo , C G , Moguilner , S , Cruzat , J , Fraile-Vazquez , M E , Herzog , R , Kringelbach , M L , Deco , G , Prado , P , Ibanez , A & Tagliazucchi , E 2023 , ' Model-based whole-brain perturbational landscape of neurodegenerative diseases ' , eLife , vol. 12 , e83970 . https://doi.org/10.7554/elife.83970 |
| سنة النشر: | 2023 |
| المجموعة: | Aarhus University: Research |
| الوصف: | The treatment of neurodegenerative diseases is hindered by lack of interventions capable of steering multimodal whole-brain dynamics towards patterns indicative of preserved brain health. To address this problem, we combined deep learning with a model capable of repro-ducing whole-brain functional connectivity in patients diagnosed with Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD). These models included disease-specific atrophy maps as priors to modulate local parameters, revealing increased stability of hippocampal and insular dynamics as signatures of brain atrophy in AD and bvFTD, respectively. Using variational autoencoders, we visualized different pathologies and their severity as the evolution of trajectories in a low-dimensional latent space. Finally, we perturbed the model to reveal key AD-and bvFTD-specific regions to induce transitions from pathological to healthy brain states. Overall, we obtained novel insights on disease progression and control by means of external stimulation, while identifying dynamical mechanisms that underlie functional alterations in neurodegeneration. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://pure.au.dk/portal/en/publications/0a4edfc6-11e1-47dc-9df6-eeea3e0888d0 |
| DOI: | 10.7554/elife.83970 |
| الاتاحة: | https://pure.au.dk/portal/en/publications/0a4edfc6-11e1-47dc-9df6-eeea3e0888d0 https://doi.org/10.7554/elife.83970 http://www.scopus.com/inward/record.url?scp=85151508830&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.8C36B759 |
| قاعدة البيانات: | BASE |
| DOI: | 10.7554/elife.83970 |
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