Academic Journal
Imipenem/Cilastatin in Acute Pulmonary Exacerbations of Cystic Fibrosis
| العنوان: | Imipenem/Cilastatin in Acute Pulmonary Exacerbations of Cystic Fibrosis |
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| المؤلفون: | Krilov, L. R., Blumer, J. L., Stern, R. C., Hartstein, A. I., Iglewski, B. N., Goldmann, D. A. |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 1985 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Session IV: Clinical Efficacy and Safety of Imipenem/Cilastatin |
| الوصف: | Nineteen patients with pulmonary exacerbations of cystic fibrosis due to Pseudomonas aeruginosa were given imipenem/cilastatin for six to 10 days at dosages of 30–90 mg/kg per day. Mean Shwachman scores rose from 46.6 to 50.3 ( P < .001), clinical efficacy scores from 34.3 to 43.3 ( P < .001), vital capacity from 53.7% to 58.5% of the predicted value ( P < .01), forced expiratory volume in I sec from 39.5% to 42.6%, and partial pressure of oxygen in arterial blood from 68.2 mm Hg to 72.6 mm Hg. Treatment failed in only two instances. The concentration of P. aeruginosa in the sputum decreased to a modest extent (8.5 log 10 , cfu/ml on day 1, 8.1 log 10 cfu/ml on day 10; P > .1). Four patients had imipenem-resistant strains of P. aeruginosa at the start of therapy, and 11 additional patients developed resistant strains during treatment; in eight patients >90% of all Pseudomonas organisms in the sputum were resistant at the end of therapy. Six patients acquired Candida in their sputum. There was no correlation between bacteriologic improvement or the development of resistance to imipenem and either clinical outcome or improvement in pulmonary function. In summary, imipenem/cilastatin therapy is associated with a good clinical outcome in patients with cystic fibrosis, but resistance emerges rapidly. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://cid.oxfordjournals.org/cgi/content/short/7/Supplement_3/S482; http://dx.doi.org/10.1093/clinids/7.Supplement_3.S482 |
| DOI: | 10.1093/clinids/7.Supplement_3.S482 |
| الاتاحة: | http://cid.oxfordjournals.org/cgi/content/short/7/Supplement_3/S482 https://doi.org/10.1093/clinids/7.Supplement_3.S482 |
| Rights: | Copyright (C) 1985, Infectious Diseases Society of America |
| رقم الانضمام: | edsbas.8C35B4D0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/clinids/7.Supplement_3.S482 |
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