التفاصيل البيبلوغرافية
| العنوان: |
Precision Polymer Particles by Flash Nanoprecipitation and Microfluidic Droplet Extraction |
| المؤلفون: |
William N. Sharratt (8437017), Victoria E. Lee (4059364), Rodney D. Priestley (1292448), João T. Cabral (1349718) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biophysics, Biotechnology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, reviewing previous work, rapid (∼ millisecond, processes including demixing, opposing jet arrangement, often using microfluidics, external flow fields, external particle morphologies, solution phase behavior, microfluidic droplet extraction, dse corresponds effectively, dilute polymer solution, precision polymer particles, droplet solvent extraction, polymer solution, solvent extraction, polymer particles, phase inversion, multiphase morphologies, droplet shrinkage, droplet prior, ternary polymer, polystyrene particles, polymer mixtures, solvent exchange |
| الوصف: |
We comparatively review two versatile approaches employed in the precise formation of polymer particles, with length scales from 10s of nm to to 100s μm, from ternary polymer(s), solvent and nonsolvent mixtures. Flash nanoprecipitation (FNP) utilizes an opposing jet arrangement to mix a dilute polymer solution and a nonsolvent in confinement, inducing a rapid (∼millisecond) chain collapse and eventual precipitation of nanoparticles (NPs) of 10–1000 nm diameters. FNP of polymer mixtures and block copolymers can yield a range of multiphase morphologies with various functionalities. While droplet solvent extraction (DSE) also involves the exposure of a polymer solution to a nonsolvent, in this case the polymer solution is templated into a droplet prior to solvent extraction, often using microfluidics, resulting in polymer particles of 1–1000 μm diameter. Droplet shrinkage and solvent exchange are generally accompanied by a series of processes including demixing, coarsening, phase inversion, skin formation, and kinetic arrest, which lead to a plethora of possible internal and external particle morphologies. In the absence of external flow fields, DSE corresponds effectively to nonsolvent induced phase separation (NIPS) in a spherical geometry. In this review, we discuss the requirements to implement both approaches, detailing consequences of ternary solution phase behavior and the interplay of the various processes underpinning particle formation and highlighting the similarities, differences, and complementarity of FNP and DSE. In addition to reviewing previous work in the field, we report comparative experimental results on the formation of polystyrene particles by both approaches, emphasizing the importance of solution phase behavior in process design. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Precision_Polymer_Particles_by_Flash_Nanoprecipitation_and_Microfluidic_Droplet_Extraction/16583624 |
| DOI: |
10.1021/acsapm.1c00546.s001 |
| الاتاحة: |
https://doi.org/10.1021/acsapm.1c00546.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.8C1E18C9 |
| قاعدة البيانات: |
BASE |