Academic Journal
The optimal number of induction chemotherapy cycles in clinically lymph node-positive bladder cancer
| العنوان: | The optimal number of induction chemotherapy cycles in clinically lymph node-positive bladder cancer |
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| المؤلفون: | von Deimling, Markus, Mertens, Laura S, Furrer, Marc, Li, Roger, Tendijck, Guus A H, Taylor, Jacob, Crocetto, Felice, Maas, Moritz, Mari, Andrea, Pichler, Renate, Moschini, Marco, Tully, Karl H, D'Andrea, David, Laukhtina, Ekaterina, Del Giudice, Francesco, Marcq, Gautier, Velev, Maud, Gallioli, Andrea, Albisinni, Simone, Mori, Keiichiro, Khanna, Abhinav, Rink, Michael, Fisch, Margit, Minervini, Andrea, Black, Peter C, Lotan, Yair, Spiess, Philippe E, Kiss, Bernhard, Shariat, Shahrokh F, Pradere, Benjamin |
| المساهمون: | von Deimling, Marku, Mertens, Laura S, Furrer, Marc, Li, Roger, Tendijck, Guus A H, Taylor, Jacob, Crocetto, Felice, Maas, Moritz, Mari, Andrea, Pichler, Renate, Moschini, Marco, Tully, Karl H, D'Andrea, David, Laukhtina, Ekaterina, Del Giudice, Francesco, Marcq, Gautier, Velev, Maud, Gallioli, Andrea, Albisinni, Simone, Mori, Keiichiro, Khanna, Abhinav, Rink, Michael, Fisch, Margit, Minervini, Andrea, Black, Peter C, Lotan, Yair, Spiess, Philippe E, Kiss, Bernhard, Shariat, Shahrokh F, Pradere, Benjamin |
| سنة النشر: | 2024 |
| المجموعة: | IRIS Università degli Studi di Napoli Federico II |
| مصطلحات موضوعية: | cN+, induction chemotherapy, pathology, survival, urinary bladder neoplasms |
| الوصف: | Objective: To investigate the optimal number of induction chemotherapy cycles needed to achieve a pathological response in patients with clinically lymph node-positive (cN+) bladder cancer (BCa) who received three or four cycles of induction chemotherapy followed by consolidative radical cystectomy (RC) with pelvic lymph node dissection. Patients and methods: We included 388 patients who received three or four cycles of cisplatin/gemcitabine or (dose-dense) methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC), followed by consolidative RC for cTanyN1-3M0 BCa. We compared pathological complete (pCR = ypT0N0) and objective response (pOR = yp ≤T1N0) between treatment groups. Predictors of pCR and/or pOR were assessed using uni- and multivariable logistic regression analysis. The secondary endpoints were overall (OS) and cancer-specific survival (CSS). We evaluated the association between the number of induction chemotherapy cycles administered and survival outcomes on multivariable Cox regression. Results: Overall, 101 and 287 patients received three or four cycles of induction chemotherapy, respectively. Of these, 72 (19%) and 128 (33%) achieved pCR and pOR response, respectively. The pCR (20%, 18%) and pOR (40%, 31%) rates did not differ significantly between patients receiving three or four cycles (P > 0.05). The number of cycles was not associated with pCR or pOR on multivariable logistic regression analyses. The 2-year OS estimates were 63% (95% confidence interval [CI] 0.53-0.74) and 63% (95% CI 0.58-0.7) for patients receiving three or four cycles, respectively. Receiving three vs four cycles was not associated with OS and CSS on uni- or multivariable Cox regression analyses. Conclusion: Pathological response and survival outcomes did not differ between administering three or four induction chemotherapy cycles in patients with cN+ BCa. A fewer cycles (minimum three) may be oncologically sufficient in patients with cN+ BCa, while decreasing the wait for definitive local therapy in those patients ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | volume:Online ahead of print.; numberofpages:9; journal:BJU INTERNATIONAL; https://hdl.handle.net/11588/962513; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85187472142 |
| DOI: | 10.1111/bju.16319 |
| الاتاحة: | https://hdl.handle.net/11588/962513 https://doi.org/10.1111/bju.16319 https://bjui-journals.onlinelibrary.wiley.com/doi/10.1111/bju.16319 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.8C17A063 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/bju.16319 |
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