Academic Journal
Heterogeneous anomalous transport in cellular and molecular biology
| العنوان: | Heterogeneous anomalous transport in cellular and molecular biology |
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| المؤلفون: | Korabel, Mykola, Waigh, Thomas Andrew |
| المصدر: | Korabel , M & Waigh , T A 2023 , ' Heterogeneous anomalous transport in cellular and molecular biology ' , Reports on Progress in Physics , vol. 86 , no. 12 , 126601 . https://doi.org/10.1088/1361-6633/ad058f |
| سنة النشر: | 2023 |
| المجموعة: | The University of Manchester: Research Explorer - Publications |
| مصطلحات موضوعية: | DNA, anomalous transport, bacteria, cellular biophysics, diffusion, motility |
| الوصف: | It is well established that a wide variety of phenomena in cellular and molecular biology involve anomalous transport e.g. the statistics for the motility of cells and molecules are fractional and do not conform to the archetypes of simple diffusion or ballistic transport. Recent research demonstrates that anomalous transport is in many cases heterogeneous in both time and space. Thus single anomalous exponents and single generalised diffusion coefficients are unable to satisfactorily describe many crucial phenomena in cellular and molecular biology. We consider advances in the field of heterogeneous anomalous transport (HAT) highlighting: experimental techniques (single molecule methods, microscopy, image analysis, fluorescence correlation spectroscopy, inelastic neutron scattering, and nuclear magnetic resonance), theoretical tools for data analysis (robust statistical methods such as first passage probabilities, survival analysis, different varieties of mean square displacements, etc), analytic theory and generative theoretical models based on simulations. Special emphasis is made on high throughput analysis techniques based on machine learning and neural networks. Furthermore, we consider anomalous transport in the context of microrheology and the heterogeneous viscoelasticity of complex fluids. HAT in the wavefronts of reaction-diffusion systems is also considered since it plays an important role in morphogenesis and signalling. In addition, we present specific examples from cellular biology including embryonic cells, leucocytes, cancer cells, bacterial cells, bacterial biofilms, and eukaryotic microorganisms. Case studies from molecular biology include DNA, membranes, endosomal transport, endoplasmic reticula, mucins, globular proteins, and amyloids. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://research.manchester.ac.uk/en/publications/a2f073e3-ddc1-4a8c-91c7-245c5c30afbb |
| DOI: | 10.1088/1361-6633/ad058f |
| الاتاحة: | https://research.manchester.ac.uk/en/publications/a2f073e3-ddc1-4a8c-91c7-245c5c30afbb https://doi.org/10.1088/1361-6633/ad058f |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.8BEFC91C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1088/1361-6633/ad058f |
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