التفاصيل البيبلوغرافية
| العنوان: |
The theoretical description for olanzapine electrochemical determination, assisted by the cobalt (III) oxyhydroxide composite with a squaraine dye ; La descripción teórica para la determinación electroquímica de olanzapina, asistida por el compuesto de oxihidróxido de cobalto (III) con un colorante de escuaraína ; A descrição teórica da detecção eletroquímica do fármaco olanzapina, assistida pelo compósito do oxihidróxido de cobalto (III) com um corante esquaraínico |
| المؤلفون: |
V. Tkach, Volodymyr, V. Kushnir, Marta, G. Ivanushko, Yana, De Oliveira, Sílvio C., dos Reis, Lucinda Vaz, Yagodynets´, Petro I., O. Kormosh, Zholt, Luganska, Olga V., V. Kopiika, Vira, V. Novosad, Natalia, O. da Silva, Adriano |
| المصدر: |
Revista Colombiana de Ciencias Químico-Farmacéuticas; Vol. 50 No. 3 (2021) ; Revista Colombiana de Ciencias Químico-Farmacéuticas; Vol. 50 Núm. 3 (2021) ; Revista Colombiana de Ciencias Químico-Farmacéuticas; v. 50 n. 3 (2021) ; 1909-6356 ; 0034-7418 |
| بيانات النشر: |
Universidad Nacional de Colombia - Sede Bogotá - Facultad de Ciencias - Departamento de Farmacia |
| سنة النشر: |
2022 |
| المجموعة: |
Universidad Nacional de Colombia: Portal de Revistas UN |
| مصطلحات موضوعية: |
olanzapina, sensores eletroquímicos, oxihidróxido de cobalto, corantes esquáricos, oscilações eletroquímicas, estado estacionário estável, olanzapine, electrochemical sensors, cobalt oxyhydroxide, squaraine dyes, electrochemical oscillations, stable steady-state, sensores electroquímicos, colorantes de escuaraína, oscilaciones electroquímicas, estado estacionario estable |
| الوصف: |
Introduction:olanzapine is one of the most used antipsychotic drugs in the world. Although it is efficient, it may be toxic in excess. Therefore, in this work the possi-bility of olanzapine electrochemical determination over an electrode, modified by the cobalt (III) oxyhydroxide in pair with its dioxide in a composite with squaraine dye. Methods:the trivariant correspondent mathematical model includes two scenarios of the drug oxidation, possible for the case, including the indirect elec-tropolymerization of the condensed benzodiazepine molecule, like also its oxidation by sulfur atom. This model has been developed and analyzed by means of stability theory and bifurcation analysis. Results and discussion: the analysis of the model has shown that the mechanism hybridity of the electroanalytical process, alongside with the formation and decomposition of ionic compounds during its realization, augments the possibility for the oscillatory behavior realization, relatively to the simplest and commonest case. Nevertheless, the oscillatory instability is realized in parameter values far beyond the detection limit. On the other hand, the stable steady-state is easy to obtain and maintain, indicating an efficient electroanalytical process, controlled by the analyte diffusion. Conclusions: t he electroanalytical process is efficient. The cobalt compound is acting as an active substance, and the dye is the mediator. ; Introducción: la olanzapina es uno de los fármacos antipsicóticos más utilizados en el mundo. Aunque es eficaz, puede resultar tóxico en exceso. Por tanto, en este trabajo se plantea la posibilidad de la determinación electroquímica de olanzapina sobre un electrodo, modificado por el oxihidróxido de cobalto (III) en pareja con su dióxido en un composito con colorante de escuaraína. Métodos: el modelo mate-mático correspondiente incluye dos escenarios de oxidación del fármaco, posibles para el caso, que incluyen la electropolimerización indirecta de la molécula de benzo-diazepina condensada, así como su ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
Spanish; Castilian |
| Relation: |
https://revistas.unal.edu.co/index.php/rccquifa/article/view/100864/82684; https://revistas.unal.edu.co/index.php/rccquifa/article/view/100864 |
| الاتاحة: |
https://revistas.unal.edu.co/index.php/rccquifa/article/view/100864 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: |
edsbas.8BEE4456 |
| قاعدة البيانات: |
BASE |