Academic Journal
Role of endothelial dysfunction in determining angina after percutaneous coronary intervention. Learning from pathophysiology to optimize treatment
| العنوان: | Role of endothelial dysfunction in determining angina after percutaneous coronary intervention. Learning from pathophysiology to optimize treatment |
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| المؤلفون: | Mangiacapra F., Del Buono M. G., Abbate A., Gori T., Barbato E., Montone R. A., Crea F., Niccoli G. |
| المساهمون: | Mangiacapra, F., Del Buono, M. G., Abbate, A., Gori, T., Barbato, E., Montone, R. A., Crea, F., Niccoli, G. |
| بيانات النشر: | Elsevier Inc. |
| سنة النشر: | 2020 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | angina, endothelial dysfunction, microvascular dysfunction, percutaneous coronary intervention, recurrent angina, angina pectori, coronary artery disease, coronary restenosi, coronary thrombosi, coronary vasospasm, coronary vessel, endothelium, vascular, hemodynamic, human, microcirculation, risk factor, stent, treatment outcome, coronary circulation |
| الوصف: | Endothelial dysfunction (EnD) is a hallmark feature of coronary artery disease (CAD), representing the key early step of atherosclerotic plaque development and progression. Percutaneous coronary intervention (PCI) is performed daily worldwide to treat symptomatic CAD, however a consistent proportion of patients remain symptomatic for angina despite otherwise successful revascularization. EnD plays a central role in the mechanisms of post-PCI angina, as it is strictly associated with both structural and functional abnormalities in the coronary arteries that may persist, or even accentuate, following PCI. The assessment of endothelial function in patients undergoing PCI might help to identify those patients at higher risk of future cardiovascular events and recurrent/persistent angina who might therefore benefit more from an intensive treatment. In this review, we address the role of EnD in determining angina after PCI, discussing its pathophysiological mechanisms, diagnostic approaches and therapeutic perspectives. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/32061633; info:eu-repo/semantics/altIdentifier/wos/WOS:000557239000006; volume:63; issue:3; firstpage:233; lastpage:242; numberofpages:10; journal:PROGRESS IN CARDIOVASCULAR DISEASES; https://hdl.handle.net/11573/1659130; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85088898484 |
| DOI: | 10.1016/j.pcad.2020.02.009 |
| الاتاحة: | https://hdl.handle.net/11573/1659130 https://doi.org/10.1016/j.pcad.2020.02.009 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.8BD2D933 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.pcad.2020.02.009 |
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