Academic Journal
Synthesis and Characterization of Paclitaxel-Loaded PEGylated Liposomes by the Microfluidics Method
| العنوان: | Synthesis and Characterization of Paclitaxel-Loaded PEGylated Liposomes by the Microfluidics Method |
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| المؤلفون: | Eman Jaradat, Edward Weaver, Adam Meziane, Dimitrios A. Lamprou |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Biochemistry, Pharmacology, Biotechnology, Space Science, Chemical Sciences not elsewhere classified, including limited solubility, dynamic light scattering, different drug concentrations, flow rate ratio, use microfluidic technology, 25 high homogeneity, produce pegylated px, enhance px solubility, possesses several limitations, loaded pegylated liposomes, drug delivery system, peg lipid ratio, microfluidic system, lipid ratio, loaded liposomes, high packing, lipid phases, stable liposomes, prepare liposomes, px encapsulation, loading px, formulate px, work aims, untargeted effects, results show |
| الوصف: | For cancer therapy, paclitaxel (PX) possesses several limitations, including limited solubility and untargeted effects. Loading PX into nanoliposomes to enhance PX solubility and target their delivery as a drug delivery system has the potential to overcome these limitations. Over the other conventional method to prepare liposomes, a microfluidic system is used to formulate PX-loaded PEGylated liposomes. The impact of changing the flow rate ratio (FRR) between the aqueous and lipid phases on the particle size and polydispersity index (PDI) is investigated. Moreover, the effect of changing the polyethylene glycol (PEG) lipid ratio on the particle size, PDI, stability, encapsulation efficiency % (EE %), and release profile is studied. The physicochemical characteristics of the obtained formulation were analyzed by dynamic light scattering, FTIR spectroscopy, and AFM. This work aims to use microfluidic technology to produce PEGylated PX-loaded liposomes with a diameter of <200 nm, low PDI < 0.25 high homogeneity, and viable 28 day stability. The results show a significant impact of FRR and PEG lipid ratio on the empty liposomes’ physicochemical characteristics. Among the prepared formulations, two formulations produce size-controlled, low PDI, and stable liposomes, which make them preferable for PX encapsulation. The average EE % was >90% for both formulations, and the variation in the PEG lipid ratio affected the EE % slightly; a high packing for PX was reported at different drug concentrations. A variation in the release profiles was notified for the different PEG lipid ratios. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/Synthesis_and_Characterization_of_Paclitaxel-Loaded_PEGylated_Liposomes_by_the_Microfluidics_Method/24514318 |
| DOI: | 10.1021/acs.molpharmaceut.3c00596.s001 |
| الاتاحة: | https://doi.org/10.1021/acs.molpharmaceut.3c00596.s001 https://figshare.com/articles/journal_contribution/Synthesis_and_Characterization_of_Paclitaxel-Loaded_PEGylated_Liposomes_by_the_Microfluidics_Method/24514318 |
| Rights: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.8BC3AD8A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acs.molpharmaceut.3c00596.s001 |
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