Academic Journal
Endocardial Regulation of Cardiac Development
| العنوان: | Endocardial Regulation of Cardiac Development |
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| المؤلفون: | Feulner, Lara, Vliet, Patrick Piet, Puceat, Michel, Andelfinger, Gregor |
| المساهمون: | Centre de recherche du CHU Sainte-Justine / Research Center of the Sainte-Justine University Hospital Montreal, Canada, Université de Montréal (UdeM)-CHU Sainte Justine Montréal, Marseille medical genetics - Centre de génétique médicale de Marseille (MMG), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), The Andelfinger lab is supported by Heart and Stroke Foundation of Canada (no. G-17-0019170) and Leducq Foundation (no. MIBAVA-Leducq 12CVD03). Additional funding was providedby Banque Nationale through a Research Excellence Chair in Cardiovascular Genetics to G.A. G.A.was supported by a Senior Research Scholarship from Fonds de Recherche Santé Québec (no. 27335).L.F. is supported by a Fonds de Recherche Santé Québec Doctoral Training Award. |
| المصدر: | EISSN: 2308-3425 ; Journal of Cardiovascular Development and Disease ; https://amu.hal.science/hal-03780347 ; Journal of Cardiovascular Development and Disease, 2022, 9 (5), ⟨10.3390/jcdd9050122⟩ |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2022 |
| المجموعة: | Aix-Marseille Université: HAL |
| مصطلحات موضوعية: | endocardium, heart development, heart disease, BMP, Notch, [SDV.GEN]Life Sciences [q-bio]/Genetics |
| الوصف: | International audience ; The endocardium is a specialized form of endothelium that lines the inner side of the heart chambers and plays a crucial role in cardiac development. While comparatively less studied than other cardiac cell types, much progress has been made in understanding the regulation of and by the endocardium over the past two decades. In this review, we will summarize what is currently known regarding endocardial origin and development, the relationship between endocardium and other cardiac cell types, and the various lineages that endocardial cells derive from and contribute to. These processes are driven by key molecular mechanisms such as Notch and BMP signaling. These pathways in particular have been well studied, but other signaling pathways and mechanical cues also play important roles. Finally, we will touch on the contribution of stem cell modeling in combination with single cell sequencing and its potential translational impact for congenital heart defects such as bicuspid aortic valves and hypoplastic left heart syndrome. The detailed understanding of cellular and molecular processes in the endocardium will be vital to further develop representative stem cell-derived models for disease modeling and regenerative medicine in the future. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | hal-03780347; https://amu.hal.science/hal-03780347; https://amu.hal.science/hal-03780347/document; https://amu.hal.science/hal-03780347/file/Feulner.pdf |
| DOI: | 10.3390/jcdd9050122 |
| الاتاحة: | https://amu.hal.science/hal-03780347 https://amu.hal.science/hal-03780347/document https://amu.hal.science/hal-03780347/file/Feulner.pdf https://doi.org/10.3390/jcdd9050122 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.8B84FD84 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/jcdd9050122 |
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