Academic Journal
De-frailing intervention for hospitalized cardiovascular patients in the TARGET-EFT randomized clinical trial
| العنوان: | De-frailing intervention for hospitalized cardiovascular patients in the TARGET-EFT randomized clinical trial |
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| المؤلفون: | Ahmad, Fayeza, Fountotos, Rosie, Goldfarb, Michael, Bharaj, Neetika, Munir, Haroon, Marsala, John, Rudski, Lawrence G, Afilalo, Jonathan |
| المساهمون: | CIHR, Fond de Recherche en Santé du Québec, McGill Faculty of Medicine and Health Sciences |
| المصدر: | European Heart Journal - Quality of Care and Clinical Outcomes ; volume 9, issue 5, page 482-489 ; ISSN 2058-5225 2058-1742 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2022 |
| الوصف: | Aims Frailty is disproportionately prevalent in cardiovascular disease patients and exacerbated during hospital admissions, heightening the risk for adverse events and functional decline. Using the Essential Frailty Toolset (EFT) to target physical weakness, cognitive impairment, malnourishment, and anaemia, we tested a multicomponent targeted intervention to de-frail older adults with acute cardiovascular conditions during their hospital admission. Methods and results The TARGET-EFT trial was a single-center randomized clinical trial at the Jewish General Hospital, Montreal, Canada. We compared a multicomponent de-frailing intervention with usual clinical care. Intervention group patients received exercise, cognitive stimulation, protein supplementation, and iron replacement, as required. In this study, the primary outcome was frailty, as assessed by the SPPB score (Short Physical Performance Battery) at discharge, and the secondary outcome was the SARC-F score (Strength, Assistance walking, Rising from chair, Climbing, Falls) assessed 30 days later. The analysis consisted of 135 patients (mean age of 79.3 years; 54% female) who survived and completed the frailty assessments. Compared with control patients, intervention group patients had a 1.52-point superior SPPB score and a 0.74-point superior SARC-F score. Subgroup analysis suggested that patients with low left ventricular ejection fraction may have attenuated benefits, and that patients who underwent invasive cardiac procedures had the greatest benefits from the intervention. Conclusion We achieved our objective of de-frailing older cardiac inpatients on a short-term basis by improving their physical performance and functioning using a pragmatic multicomponent intervention. This could have positive impacts on their clinical outcomes and ability to maintain independent living in the future. One sentence summary The multicomponent intervention targeted to the deficits of vulnerable older adults hospitalized with acute cardiovascular diseases ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/ehjqcco/qcac050 |
| DOI: | 10.1093/ehjqcco/qcac050/45956347/qcac050.pdf |
| الاتاحة: | http://dx.doi.org/10.1093/ehjqcco/qcac050 https://academic.oup.com/ehjqcco/advance-article-pdf/doi/10.1093/ehjqcco/qcac050/45956347/qcac050.pdf https://academic.oup.com/ehjqcco/article-pdf/9/5/482/51045960/qcac050.pdf |
| Rights: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
| رقم الانضمام: | edsbas.8B603FF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ehjqcco/qcac050 |
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