Dissertation/ Thesis
Análises química, antioxidante e e citotoxicidade em linhagens tumorais de germoplasma de Eplingiella fruticosa
| العنوان: | Análises química, antioxidante e e citotoxicidade em linhagens tumorais de germoplasma de Eplingiella fruticosa |
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| المؤلفون: | Pinto, Jéssika Andreza Oliveira |
| المساهمون: | Arrigoni-Blank, Maria de Fátima |
| بيانات النشر: | Pós-Graduação em Agricultura e Biodiversidade Universidade Federal de Sergipe |
| سنة النشر: | 2022 |
| المجموعة: | Repositório Institucional da Universidade Federal de Sergipe (RIUFS) |
| مصطلحات موضوعية: | Eplingiella fruticosa, Óleo essencial, Extratos, Atividade biológica, Alecrim-de-vaqueiro, Essential oil, Biological activity, Extracts, CIENCIAS AGRARIAS |
| الوصف: | Eplingiella fruticosa is an aromatic plant of the Lamiaceae family known as “alecrim-devaqueiro”. Its popular use has aroused the interest of the scientific community regarding the possible pharmacological properties involved, and the anti-hyperalgesic, antinociceptive, antiinflammatory, vasodilatory and anti-neurodegenerative effects have already been attributed to its essential oil and extracts. The first article investigated the variations in the chemical profiles and biological activities (antioxidant and cytotoxicity) of Eplingiella fruticosa from the State of Sergipe. The essential oils of six populations were extracted by hydrodistillation and analyzed by Gas Chromatography coupled to a Mass Spectrometer and a Flame Ionization Detector (GC/EM-DIC). The antioxidant activity of the essential oils was tested by different assays (DPPH, ABTS, β-carotene and FRAP) and the cytotoxic activity was determined by the SRB assay. The compounds found in greater amounts were: α-pinene, β-pinene, 1,8-cineole, camphor, borneol, δ-elemene, α-cubebene, α-ylangeno, (E)-caryophyllene, germacrene D, bicyclogermacrene, trans -calamenene, spathulenol, caryophyllene oxide and viridiflorol. These compounds defined the formation of two groups. The first group consisted of the populations of São Cristóvão, Itaporanga, Japaratuba and Malhada dos Bois and was characterized by the presence of camphor monoterpene (8.39-11.27%) as the highest content compound in relation to the other municipalities. The second group consisted of the populations of Moita Bonita and Pirambu and was characterized by the majority presence of bicyclogermacrene sesquiterpene (7.45% and 10.98%). The plants showed weak effects in terms of antioxidant activity, but the essential oil showed significant toxicity for the A549 strains (51.00% cell viability) in the population of Japaratuba and B16F10 (64.94.6% of cell viability) in Malhada of the Oxen. The second article analyzed the chemical profile, antioxidant activity and cytotoxicity of aqueous and ethanolic ... |
| نوع الوثيقة: | thesis |
| وصف الملف: | application/pdf |
| اللغة: | Portuguese |
| Relation: | https://ri.ufs.br/jspui/handle/riufs/17970 |
| الاتاحة: | https://ri.ufs.br/jspui/handle/riufs/17970 |
| رقم الانضمام: | edsbas.8B3B0DF3 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |