Academic Journal
Argyrophilic Nucleolar Organizer Regions as New Biomarkers in ST-Elevation Myocardial Infarction
| العنوان: | Argyrophilic Nucleolar Organizer Regions as New Biomarkers in ST-Elevation Myocardial Infarction |
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| المؤلفون: | Damar, İbrahim Halil, Eröz, Recep |
| بيانات النشر: | Mdpi |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Agnor, Hypoxia, Ischemia, Stemi, Protein-Synthesis, Inflammation, Cells |
| الوصف: | (1) Background: ST-elevation myocardial infarction (STEMI) is an inflammatory disease in which neutrophils, macrophages, and lymphocytes accumulate in the ischemic myocardium and have important functions. Nucleolar-organizing regions (NORs) are the site of the ribosomal genes composed of ribosomal DNA and proteins. We aimed to evaluate AgNOR proteins, which have never been studied in patients with STEMI in the literature. (2) Methods: A total of 140 participants (75 with STEMI and 65 volunteers without any diagnosis of acute coronary syndrome) were included in this study. Echocardiography was carried out, and mean AgNOR number and total AgNOR area/total nuclear area (TAA/TNA) were evaluated for all individuals. (3) Results: The mean AgNOR number and TAA/TNA ratio were significantly higher in the STEMI group than the control (p < 0.001). Statistically significant relations between both TAA/TNA ratio and mean AgNOR number and interventricular septal thickness, fasting blood sugar, creatinine, HDL, hemoglobin (g/dL), WBC (mu L/mL), monocytes, neutrophils, and neutrophil/lymphocyte ratio were detected (p < 0.05). Moreover, a statistically significant relation between LDL (mg/dL) and mean AgNOR number (p = 0.005) was detected. (4) Conclusion: Both AgNOR protein amounts increase depending on the hypoxia that occurs in STEMI. The AgNOR proteins may thus be promising markers in STEMI. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2308-3425 |
| Relation: | Journal of Cardiovascular Development and Disease; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.3390/jcdd9020058; https://hdl.handle.net/20.500.12684/13418; 2-s2.0-85125049313; WOS:000764087100001 |
| DOI: | 10.3390/jcdd9020058 |
| الاتاحة: | https://hdl.handle.net/20.500.12684/13418 https://doi.org/10.3390/jcdd9020058 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.8B2A023A |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23083425 |
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| DOI: | 10.3390/jcdd9020058 |