Academic Journal
Susceptibility of porcine cytomegalovirus to antiviral drugs
| العنوان: | Susceptibility of porcine cytomegalovirus to antiviral drugs |
|---|---|
| المؤلفون: | Jacqueline F. L. Fryer, Paul D. Griffiths, Vincent C. Emery, Duncan A. Clark |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://jac.oxfordjournals.org/content/early/2004/04/29/jac.dkh231.full.pdf. |
| سنة النشر: | 2004 |
| المجموعة: | CiteSeerX |
| مصطلحات موضوعية: | xenotransplantation, ganciclovir, cidofovir |
| الوصف: | Objectives: Re-activation of porcine cytomegalovirus (PCMV) in the xenograft has been reported in pig-to-baboon models of xenotransplantation and is associated with invasive disease and consumptive coagu-lopathy. If xenotransplantation of porcine organs into human recipients is to proceed, donor organs will have to be free from a wide range of infectious agents including PCMV. However, it is prudent to characterize the antiviral susceptibility of this virus. We therefore investigated the effect of selected antiviral agents, currently licensed for the treatment of human herpesvirus infections, on PCMV replication. Methods: Antiviral susceptibility was determined using real-time PCR and indirect immunofluorescence measurements in a porcine fallopian tube cell line infected with PCMV. Results: PCMV replication was significantly inhibited by ganciclovir and cidofovir (both EC50 < 1 mg/L) and to a lesser extent by foscarnet (EC50 within range 25–50 mg/L) and aciclovir (EC50> 25 mg/L). Conclusions: These results show that, if it proves necessary, ganciclovir and cidofovir should be consid-ered as first-line drugs to treat PCMV infections in xenograft recipients. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.619.6874; http://jac.oxfordjournals.org/content/early/2004/04/29/jac.dkh231.full.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.619.6874 http://jac.oxfordjournals.org/content/early/2004/04/29/jac.dkh231.full.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.8B07E7A7 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |