Academic Journal
Novel Antibacterial Coating on Orthopedic Wires To Eliminate Pin Tract Infections
| العنوان: | Novel Antibacterial Coating on Orthopedic Wires To Eliminate Pin Tract Infections |
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| المؤلفون: | Gil, Dmitry, Shuvaev, Sergey, Frank-Kamenetskii, Anastasia, Reukov, Vladimir, Gross, Christopher, Vertegel, Alexey |
| المساهمون: | HHS | National Institutes of Health, Clemson University |
| المصدر: | Antimicrobial Agents and Chemotherapy ; volume 61, issue 7 ; ISSN 0066-4804 1098-6596 |
| بيانات النشر: | American Society for Microbiology |
| سنة النشر: | 2017 |
| الوصف: | Novel approaches to the prevention of microbial infections after the insertion of orthopedic external fixators are in great demand because of the extremely high incidence rates of such infections, which can reach up to 100% with longer implant residence times. Monolaurin is an antimicrobial agent with a known safety record that is broadly used in the food and cosmetic industries; however, its use in antimicrobial coatings of medical devices has not been studied in much detail. Here, we report the use of monolaurin as an antibacterial coating on external fixators for the first time. Monolaurin-coated Kirschner wires (K-wires) showed excellent antibacterial properties against three different bacterial strains, i.e., methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA), and Staphylococcus epidermidis . Approximately 6.0-log reductions of both planktonic and adherent bacteria were achieved using monolaurin-coated K-wires, but monolaurin-coated K-wires did not show any observable cytotoxicity with mouse osteoblast cell cultures. Overall, monolaurin-coated K-wires could be promising as potent antimicrobial materials for orthopedic surgery. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1128/aac.00442-17 |
| DOI: | 10.1128/AAC.00442-17 |
| الاتاحة: | http://dx.doi.org/10.1128/aac.00442-17 https://journals.asm.org/doi/pdf/10.1128/AAC.00442-17 |
| Rights: | https://journals.asm.org/non-commercial-tdm-license |
| رقم الانضمام: | edsbas.8ADEAFDF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/aac.00442-17 |
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