Academic Journal
Long‐Term Antidepressant Treatment Reduces Behavioural Deficits in Transgenic Mice with Impaired Glucocorticoid Receptor Function
| العنوان: | Long‐Term Antidepressant Treatment Reduces Behavioural Deficits in Transgenic Mice with Impaired Glucocorticoid Receptor Function |
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| المؤلفون: | Montkowski, Alexandra, Barden, Nicholas, Wotjak, Carsten, Stec, Ingemar, Ganster, Julia, Meaney, Michael, Engelmann, Mario, Reul, Johannes M. H. M., Landgraf, Rainer, Holsboer, Florian |
| المصدر: | Journal of Neuroendocrinology ; volume 7, issue 11, page 841-845 ; ISSN 0953-8194 1365-2826 |
| بيانات النشر: | Wiley |
| سنة النشر: | 1995 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Impaired cognitive function and enhanced activity of the hypothalamic‐pituitary‐adrenocortical system are among the cardinal symptoms of major depression in humans that resolve after successful antidepressant treatment. We used a transgenic mouse model expressing antisense RNA complementary to that of glucocorticoid receptor (GR) mRNA to test the hypothesis that reduced GR function can cause these clinical disturbances. The transgenic mice show profound behavioural changes in a number of animal tests that are indicative of cognitive impairment. These mice also have elevated plasma corticotropin concentrations in response to stress. After long‐term treatment with moclobemide, a reversible inhibitor of monoamine oxidase type A that acts clinically as an antidepressant, both the behavioural deficits and the hormonal alterations disappeared. These observations suggest that a transgenic mouse with GR dysfunction may be a useful model for investigation of drug effects on the cognitive and neuroendocrine aspects of depression. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/j.1365-2826.1995.tb00724.x |
| الاتاحة: | http://dx.doi.org/10.1111/j.1365-2826.1995.tb00724.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2826.1995.tb00724.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2826.1995.tb00724.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.8AD206DF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1365-2826.1995.tb00724.x |
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