التفاصيل البيبلوغرافية
| العنوان: |
A Literature Review Examining Primary Outcomes of Medication Treatment Studies for Opioid use Disorder: What outcome should be used to measure opioid treatment success? |
| المؤلفون: |
Biondi, Breanne E., Zheng, Xiaoying, Frank, Cynthia A., Petrakis, Ismene, Springer, Sandra A. |
| المصدر: |
Am J Addict |
| سنة النشر: |
2020 |
| مصطلحات موضوعية: |
Article, hisphilso, envir |
| الوصف: |
BACKGROUND AND OBJECTIVES: Medications for opioid use disorder (MOUD) reduce opioid use and overdose; however, MOUD clinical trials have used varying primary outcomes to document treatment success. We conducted a literature review to assess and critically examine the methodologies used in MOUD treatment studies. METHODS: Published studies in English that examined MOUD (buprenorphine, methadone, or extended-release naltrexone (XR-NTX)) were included. The methods and frequencies of measuring primary opioid outcomes, including urine drug tests (UDTs) and self-report of opioid use were compared among studies. RESULTS: A total of 20 studies fit the inclusion criteria. Each study assessed opioid use; only 12 had opioid use as a primary outcome. Other primary outcomes included retention in treatment (N=6), and 2 had other primary outcomes (death and opioid withdrawal symptoms). Opioid use was assessed through both self-report and UDTs in 15 studies. Two studies did not use UDTs. Differences were found in the methods used for how opioid use, retention in treatment, self-report of opioid use, and UDTs were measured. DISCUSSION AND CONCLUSIONS: The different primary outcomes used and operational definitions in each study make comparisons between studies difficult. The use of both self-report and UDTs for opioid use has several advantages, and if possible, researchers should use both measures. SCIENTIFIC SIGNIFICANCE: This is the first review critically examining outcome measures from MOUD treatment studies. Creating a standard for opioid treatment outcomes in MOUD studies will allow for generalizable results that can inform both researchers and clinicians to better care for those with OUD. |
| نوع الوثيقة: |
text |
| اللغة: |
English |
| Relation: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377168/ |
| الاتاحة: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377168/ |
| Rights: |
undefined |
| رقم الانضمام: |
edsbas.8ACA2D4C |
| قاعدة البيانات: |
BASE |