Academic Journal
Validation of a UPDRS-/MDS-UPDRS-based definition of functional dependency for Parkinson's disease.
| العنوان: | Validation of a UPDRS-/MDS-UPDRS-based definition of functional dependency for Parkinson's disease. |
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| المؤلفون: | Ramsay, Neil, Macleod, Angus D, Alves, Guido, Camacho, Marta, Forsgren, Lars, Lawson, Rachael A, Maple-Grødem, Jodi, Tysnes, Ole-Bjørn, Williams-Gray, Caroline H, Yarnall, Alison J, Counsell, Carl E, Parkinson's Incidence Cohorts Collaboration, PINE Study, CamPaIGN study, PICNICS study, NYPUM Study, ParkWest Study: ParkWest Principal investigators, Study personnel, ICICLE-PD Study |
| بيانات النشر: | Elsevier BV Parkinsonism Relat Disord |
| سنة النشر: | 2020 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | Dependency, Measurement scales, Parkinson's disease, Validation, Aged, Algorithms, Cohort Studies, Female, Functional Status, Humans, Male, Mental Status and Dementia Tests, Middle Aged, Parkinson Disease, Reproducibility of Results, Sensitivity and Specificity |
| الوصف: | INTRODUCTION: Functional dependency in basic activities of daily living (ADLs) is a key outcome in Parkinson's disease (PD). We aimed to define dependency in PD, using the original and MDS versions of the Unified Parkinson's Disease Rating Scale (UPDRS). METHODS: We developed two algorithms to define dependency from items of UPDRS Part 2 and MDS-UPDRS Part 2 relating to basic ADLs (feeding, dressing, hygiene and walking, and getting out of a chair). We validated both algorithms using data from 1110 patients from six community-based PD incidence cohorts, testing concurrent validity, convergent validity, and predictive validity. RESULTS: Our optimal algorithm showed high specificity and moderate to high sensitivity versus Schwab & England <80% (specificity 95% [95% confidence interval (CI) 93-97] and sensitivity 65% [95% CI 55-73] at baseline; 88% [95% CI 85-91] and 85% [95% CI 79-97] respectively at five-years follow-up). Convergent validity was demonstrated by strong associations between dependency defined by the algorithm and cognition (MMSE), quality of life (PDQ39), and impairment (UPDRS part 3) (all p < 0.001). Algorithm-defined dependency status also predicted mortality: HR for mortality in those dependent vs independent at baseline was 1.6 (95%CI 1.2-2.1) and in those dependent vs independent at five-years' follow-up was 2.2 (1.6-3.0). DISCUSSION: We have demonstrated the concurrent validity, convergent validity, and predictive validity of a UPDRS-/MDS-UPDRS-based algorithm to define functional dependency in PD. This can be used for studying dependency in any study where UPDRS or MDS-UPDRS part 2 data have been collected. ; The PICC collaboration was funded by the Chief Scientist Office of the Scottish Government, NHS Education for Scotland, and the Academy of Medical Sciences. The CamPaIGN study has received funding from the Wellcome Trust, the Medical Research Council, the Patrick Berthoud Trust, Parkinson’s UK, and the National Institute for Health Research (NIHR) Cambridge Biomedical Research ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | Print-Electronic; application/pdf |
| اللغة: | English |
| Relation: | https://www.repository.cam.ac.uk/handle/1810/306605 |
| DOI: | 10.17863/CAM.53689 |
| الاتاحة: | https://doi.org/10.17863/CAM.53689 https://www.repository.cam.ac.uk/handle/1810/306605 |
| Rights: | Attribution-NonCommercial-NoDerivatives 4.0 International ; https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.8AB56E88 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.53689 |
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