Review
Acute benzodiazepine administration induces changes in homocysteine metabolism in young healthy volunteers
| العنوان: | Acute benzodiazepine administration induces changes in homocysteine metabolism in young healthy volunteers |
|---|---|
| المؤلفون: | Pompeia, Sabine UNIFESP, Grego, Bruno H. C. UNIFESP, Pradella-Hallinan, Marcia UNIFESP, Hachul, Helena UNIFESP, Tufik, Sergio UNIFESP, D'Almeida, Vania UNIFESP |
| المساهمون: | Universidade Federal de São Paulo (UNIFESP) |
| بيانات النشر: | Elsevier B.V. |
| سنة النشر: | 2009 |
| المجموعة: | Universidade Federal de São Paulo (UNIFESP): Repositório Institucional |
| مصطلحات موضوعية: | Benzodiazepine, Cortisol, Cysteine, Gender, Homocysteine |
| الوصف: | Purpose: High cortisol plasma concentrations have been shown to be associated with increases in homocysteine levels. Here we studied whether decreases in cortisol concentration, induced by an acute oral dose of a benzodiazepine, could decrease homocysteine, and if changes were similar in both genders.Methods: This was a double-blind, cross-over design study of acute oral flunitrazepam (1.2 mg) and placebo in young, healthy, male and female (n = 21) volunteers. Blood samples were collected 3 h after ingestion (after peak-plasma concentration of flunitrazepam was reached). Various biochemical parameters were analysed, such as plasma homocysteine, cysteine, folate, vitamins B6, B12, and sexual hormones.Results: Flunitrazepam reduced cortisol (p = 0.0011), cysteine (p = 0.014) and homocysteine (p = 0.028) concentrations, irrespective of gender. No correlations were found between cortisol and other biochemical markers (all r's<0.03). Concentration of cysteine and homocysteine were negatively correlated with plasma flunitrazepam concentration, suggesting that changes in these amino acids might be related to the metabolism of this benzodiazepine.Conclusion: Acute administration of flunitrazepam decreases plasma homocysteine and cysteine by mechanisms that seem unrelated to changes in cortisol. Given the importance of homocysteine as a market of life-threatening disorders, the mechanisms involved in the decrease of these amino acids are potential targets for clinical application. (C) 2009 Elsevier Inc. All rights reserved. ; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) ; AFIP ; Universidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil ; Universidade Federal de São Paulo, Dept Biosci, BR-04024002 São Paulo, Brazil ; Universidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil ; Universidade Federal de São Paulo, Dept Biosci, BR-04024002 São Paulo, Brazil ; FAPESP: 2005/03552-8 ; FAPESP: ... |
| نوع الوثيقة: | review |
| وصف الملف: | 933-938 |
| اللغة: | English |
| تدمد: | 0278-5846 |
| Relation: | Progress in Neuro-psychopharmacology & Biological Psychiatry; http://dx.doi.org/10.1016/j.pnpbp.2009.04.017; Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 33, n. 6, p. 933-938, 2009.; http://repositorio.unifesp.br/handle/11600/31750; WOS:000269300600003 |
| DOI: | 10.1016/j.pnpbp.2009.04.017 |
| الاتاحة: | http://repositorio.unifesp.br/handle/11600/31750 https://doi.org/10.1016/j.pnpbp.2009.04.017 |
| Rights: | Acesso restrito ; http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
| رقم الانضمام: | edsbas.8A9433C8 |
| قاعدة البيانات: | BASE |
| تدمد: | 02785846 |
|---|---|
| DOI: | 10.1016/j.pnpbp.2009.04.017 |