Academic Journal
Design, synthesis and biological evaluation of 3,5-diaryl isoxazole derivatives as potential anticancer agents
| العنوان: | Design, synthesis and biological evaluation of 3,5-diaryl isoxazole derivatives as potential anticancer agents |
|---|---|
| المؤلفون: | Akinalp, Gökçen, Algul, Oztekin, Karatas, Omer Faruk, Nicolotti, Orazio, Gambacorta, Nicola, Yucel, Mehmet Ali, Sanli, Fatma, Aktaş, Derya, Burmaoğlu, Serdar |
| سنة النشر: | 2020 |
| الوصف: | The present study was carried out in the attempt to synthesize a new class of potential anticancer agents comprising eleven compounds (24-34) sharing the 3,5-diarylisoxazole as a core. The chemical structure of the new synthesized compounds was established by IR, H-1 NMR, C-13 NMR and elemental analysis. Their biological potential towards prostate cancer was evaluated by using cancer PC3 cells and non-tumorigenic PNT1a cells. Interestingly, compound 26 distinguished from others with a quite high selectivity value that is comparable to 5-FU. The binding mode of 26 towards Ribosomal protein S6 kinase beta-1 (S6K1) was investigated at a molecular level of detail by employing docking simulations based on GLIDE standard precision as well as MM-GBSA calculations. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | d561c064-57d9-4b05-9f73-4faf04e2650e; https://avesis.atauni.edu.tr/publication/details/d561c064-57d9-4b05-9f73-4faf04e2650e/oai |
| DOI: | 10.1016/j.bmcl.2020.127427 |
| الاتاحة: | https://doi.org/10.1016/j.bmcl.2020.127427 https://avesis.atauni.edu.tr/publication/details/d561c064-57d9-4b05-9f73-4faf04e2650e/oai |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.8A325263 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.bmcl.2020.127427 |
|---|