التفاصيل البيبلوغرافية
| العنوان: |
Flow Synthesis of L-α-Glycerylphosphorylcholine: Studies on Synthetic Routes Applicable to a Flow Reactor and Optimization of Reaction Conditions |
| المؤلفون: |
Jihun Park, Seungjae Lee, Gyungtak Kim, Yashwardhan R. Malpani, Boyoung Y. Park, Ye-Jin Hwang |
| المصدر: |
Pharmaceutics; Volume 14; Issue 11; Pages: 2480 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2022 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
L-α-Glycerylphosphorylcholine, L-α-GPC, flow chemistry, phosphoryl choline, flow reactor |
| الوصف: |
L-α-Glycerylphosphorylcholine (L-α-GPC) has mainly been produced by two methods: extraction from plants rich in phosphatidylcholine and chemical synthesis. However, production through extraction involves difficult processes, such as fermentation, extractions and ripening, and conventional chemical synthesis methods with high-cost reactants and a batch reactor. These methods are not ideal for large-quantity production. Thus, it is important to develop a simple production method of L-α-GPC, which is suitable for mass production without the need for expensive reactants. Here, we studied synthetic L-α-GPC methods that are applicable to a flow synthesis system, which can provide selectivity, reproducibility, scalability, and a high yield in short reaction time using inexpensive starting materials. We developed a two-step synthetic route to produce L-α-GPC, including the synthesis of phosphoryl choline using choline chloride and phosphoryl oxychloride (POCl3) as a first step and synthesis of L-α-GPC by reacting phosphoryl choline with (R)-(−)-3-chloro-1,2-propanediol (CPD) as a second step under basic conditions. Both steps were separately performed in a customized flow reactor, and reaction conditions were optimized. Finally, phosphoryl choline and L-α-GPC, the products first and second reactions, were successfully synthesized with high conversion yields of 97% and 79%, respectively. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
https://dx.doi.org/10.3390/pharmaceutics14112480 |
| DOI: |
10.3390/pharmaceutics14112480 |
| الاتاحة: |
https://doi.org/10.3390/pharmaceutics14112480 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.8A25F7DA |
| قاعدة البيانات: |
BASE |