Academic Journal
Biological and Biochemical Basis of the Differential Efficacy of First and Second Generation Somatostatin Receptor Ligands in Neuroendocrine Neoplasms
| العنوان: | Biological and Biochemical Basis of the Differential Efficacy of First and Second Generation Somatostatin Receptor Ligands in Neuroendocrine Neoplasms |
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| المؤلفون: | Gatto, Federico, Barbieri, Federica, Arvigo, Marica, Thellung, Stefano, Amarù, Jessica, Albertelli, Manuela, Ferone, Diego, Florio, Tullio |
| المساهمون: | Gatto, Federico, Barbieri, Federica, Arvigo, Marica, Thellung, Stefano, Amarù, Jessica, Albertelli, Manuela, Ferone, Diego, Florio, Tullio |
| بيانات النشر: | MDPI CHE |
| سنة النشر: | 2019 |
| المجموعة: | Università degli Studi di Genova: CINECA IRIS |
| مصطلحات موضوعية: | neuroendocrine tumors, pituitary adenomas, somatostatin receptor ligands, somatostatin receptors |
| الوصف: | Endogenous somatostatin shows anti-secretory effects in both physiological and pathological settings, as well as inhibitory activity on cell growth. Since somatostatin is not suitable for clinical practice, researchers developed synthetic somatostatin receptor ligands (SRLs) to overcome this limitation. Currently, SRLs represent pivotal tools in the treatment algorithm of neuroendocrine tumors (NETs). Octreotide and lanreotide are the first-generation SRLs developed and show a preferential binding affinity to somatostatin receptor (SST) subtype 2, while pasireotide, which is a second-generation SRL, has high affinity for multiple SSTs (SST5 > SST2 > SST3 > SST1). A number of studies demonstrated that first-generation and second-generation SRLs show distinct functional properties, besides the mere receptor affinity. Therefore, the aim of the present review is to critically review the current evidence on the biological effects of SRLs in pituitary adenomas and neuroendocrine tumors, by mainly focusing on the differences between first-generation and second-generation ligands. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/31412614; info:eu-repo/semantics/altIdentifier/wos/WOS:000484411100097; volume:20 (16) art num 3940; firstpage:1; lastpage:31; numberofpages:31; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; http://hdl.handle.net/11567/970419; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85071167624 |
| DOI: | 10.3390/ijms20163940 |
| الاتاحة: | http://hdl.handle.net/11567/970419 https://doi.org/10.3390/ijms20163940 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.8A1ADF44 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms20163940 |
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