Academic Journal
A functional microsatellite of the macrophage migration inhibitory factor gene associated with meningococcal disease.
| العنوان: | A functional microsatellite of the macrophage migration inhibitory factor gene associated with meningococcal disease. |
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| المؤلفون: | Renner, P., Roger, T., Bochud, P.Y., Sprong, T., Sweep, C.G.J., Bochud, M., Faust, S.N., Haralambous, E., Betts, H., Chanson, A.L., Reymond, M.K., Mermel, E., Erard, V., Deuren, M. van, Read, R.C., Levin, M., Calandra, T |
| المصدر: | The Faseb Journal, 26, 2, pp. 907-16 |
| سنة النشر: | 2012 |
| المجموعة: | Radboud University: DSpace |
| مصطلحات موضوعية: | IGMD 6: Hormonal regulation ONCOL 5: Aetiology, screening and detection, N4i 1: Pathogenesis and modulation of inflammation |
| الوصف: | Item does not contain fulltext ; Macrophage migration inhibitory factor (MIF) is an abundantly expressed proinflammatory cytokine playing a critical role in innate immunity and sepsis and other inflammatory diseases. We examined whether functional MIF gene polymorphisms (-794 CATT(5-8) microsatellite and -173 G/C SNP) were associated with the occurrence and outcome of meningococcal disease in children. The CATT(5) allele was associated with the probability of death predicted by the Pediatric Index of Mortality 2 (P=0.001), which increased in correlation with the CATT(5) copy number (P=0.04). The CATT(5) allele, but not the -173 G/C alleles, was also associated with the actual mortality from meningoccal sepsis [OR 2.72 (1.2-6.4), P=0.02]. A family-based association test (i.e., transmission disequilibrium test) performed in 240 trios with 1 afflicted offspring indicated that CATT(5) was a protective allele (P=0.02) for the occurrence of meningococcal disease. At baseline and after stimulation with Neisseria meningitidis in THP-1 monocytic cells or in a whole-blood assay, CATT(5) was found to be a low-expression MIF allele (P=0.005 and P=0.04 for transcriptional activity; P=0.09 and P=0.09 for MIF production). Taken together, these data suggest that polymorphisms of the MIF gene affecting MIF expression are associated with the occurrence, severity, and outcome of meningococcal disease in children. ; 01 februari 2012 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | http://hdl.handle.net/2066/110607; https://doi.org/10.1096/fj.11-195065 |
| DOI: | 10.1096/fj.11-195065 |
| الاتاحة: | http://hdl.handle.net/2066/110607 https://doi.org/10.1096/fj.11-195065 |
| رقم الانضمام: | edsbas.89DEB1CD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1096/fj.11-195065 |
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