Academic Journal
Association of HLA‐ DRB1 and HLA‐ DQB1 with red‐blood‐cell alloimmunization in the Czech population
| العنوان: | Association of HLA‐ DRB1 and HLA‐ DQB1 with red‐blood‐cell alloimmunization in the Czech population |
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| المؤلفون: | Maluskova, A., Mrazek, F., Pauliskova, M., Kovarova, P., Koristka, M., Jindra, P., Cermakova, Z. |
| المساهمون: | University Hospital Ostrava, Palacky University Olomouc |
| المصدر: | Vox Sanguinis ; volume 112, issue 2, page 156-162 ; ISSN 0042-9007 1423-0410 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2017 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background and Objectives Alloimmune antibodies against red‐blood‐cell ( RBC ) antigens induced in susceptible individuals (responders) by transfusion, pregnancy or transplantation may have serious clinical consequences. The aim of this study was to investigate association of alloimmunization against selected RBC antigens with HLA ‐Class II . Materials and Methods A total of 230 responders (106 monoresponders and 124 multiresponders) were enrolled into the study. HLA ‐ DRB 1 and HLA ‐ DQB 1 variants were determined by PCR ‐ SSO and their frequencies compared between the patients (patient subgroups) and 375 ethnically and regionally matched controls. Results Development of multiple RBC antibodies was associated with HLA ‐ DRB 1*15 and HLA ‐ DQB 1*06 allelic groups in the patients, with the relationship being particularly apparent in those with anti‐C+D antibodies. Furthermore, DRB 1*13 and DQB 1*06 were more frequent in multiresponders with anti‐E+c antibodies and DRB 1*03 and DQB 1*02 in those with anti‐E+Cw. Conclusion For the first time, we confirmed the association of HLA ‐ DRB 1*15 with RBC antibody multiresponder status and found HLA ‐Class II associations for three frequent RBC antibody combinations. Our data support the concept that HLA restriction plays an important role in the response to RBC alloantigens. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/vox.12478 |
| الاتاحة: | http://dx.doi.org/10.1111/vox.12478 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fvox.12478 https://onlinelibrary.wiley.com/doi/pdf/10.1111/vox.12478 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.89C158D6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/vox.12478 |
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