Academic Journal
Different SWI/SNF complexes coordinately promote R-loop- and RAD52-dependent transcription-coupled homologous recombination
| العنوان: | Different SWI/SNF complexes coordinately promote R-loop- and RAD52-dependent transcription-coupled homologous recombination |
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| المؤلفون: | Davó-Martínez, Carlota, Helfricht, Angela, Ribeiro-Silva, Cristina, Raams, Anja, Tresini, Maria, Uruci, Sidrit, van Cappellen, Wiggert A., Taneja, Nitika, Demmers, Jeroen A.A., Pines, Alex, Theil, Arjan F., Vermeulen, Wim, Lans, Hannes |
| المصدر: | Davó-Martínez , C , Helfricht , A , Ribeiro-Silva , C , Raams , A , Tresini , M , Uruci , S , van Cappellen , W A , Taneja , N , Demmers , J A A , Pines , A , Theil , A F , Vermeulen , W & Lans , H 2023 , ' Different SWI/SNF complexes coordinately promote R-loop- and RAD52-dependent transcription-coupled homologous recombination ' , Nucleic Acids Research , vol. 51 , no. 17 , pp. 9055-9074 . https://doi.org/10.1093/nar/gkad609 |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being |
| الوصف: | The SWI/SNF family of ATP-dependent chromatin remodeling complexes is implicated in multiple DNA damage response mechanisms and frequently mutated in cancer. The BAF, PBAF and ncBAF complexes are three major types of SWI/SNF complexes that are functionally distinguished by their exclusive subunits. Accumulating evidence suggests that double-strand breaks (DSBs) in transcriptionally active DNA are preferentially repaired by a dedicated homologous recombination pathway. We show that different BAF, PBAF and ncBAF subunits promote homologous recombination and are rapidly recruited to DSBs in a transcription-dependent manner. The PBAF and ncBAF complexes promote RNA polymerase II eviction near DNA damage to rapidly initiate transcriptional silencing, while the BAF complex helps to maintain this transcriptional silencing. Furthermore, ARID1A-containing BAF complexes promote RNaseH1 and RAD52 recruitment to facilitate R-loop resolution and DNA repair. Our results highlight how multiple SWI/SNF complexes perform different functions to enable DNA repair in the context of actively transcribed genes. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1093/nar/gkad609 |
| الاتاحة: | https://pure.eur.nl/en/publications/1062e8ef-8f15-4f70-977c-866ccd16b5e6 https://doi.org/10.1093/nar/gkad609 https://pure.eur.nl/ws/files/168310181/gkad609.pdf http://www.scopus.com/inward/record.url?scp=85172424374&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.8973013 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/nar/gkad609 |
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