التفاصيل البيبلوغرافية
| العنوان: |
Additional file 2 of Immunological and genetic kinetics from diagnosis to clinical progression in chronic lymphocytic leukemia |
| المؤلفون: |
Isabel Jiménez (10836624), Bárbara Tazón-Vega (10836627), Pau Abrisqueta (492241), Juan C. Nieto (10836630), Sabela Bobillo (10836633), Carles Palacio-García (10836636), Júlia Carabia (492242), Rafael Valdés-Mas (110702), Magdalena Munuera (10836639), Lluís Puigdefàbregas (10836642), Genís Parra (10836645), Anna Esteve-Codina (3260481), Clara Franco-Jarava (7447034), Gloria Iacoboni (10836648), María José Terol (10836651), José Antonio García-Marco (10836654), Marta Crespo (492243), Francesc Bosch (10836657) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Immunology, CLL, Immune evasion, Clinical progression, T cell exhaustion |
| الوصف: |
Additional file 2: Supplementary Table S1. Monoclonal antibodies (mAbs). Supplementary Table S7. Highlighted dysregulated genes in T CLL cells at progression. Supplementary Figure S1. Longitudinal analysis of the CCF of CNVs from paired B-CLL cells at diagnosis and progression before treatment. Comparison of the CCF with 95% CI for each CNV detected per patient (n = 10) between diagnosis and progression. Significantly increased (red lines) and stable CCF (grey lines) are shown. Recurrent CNVs in CLL (del(13q), del(11q), del(17p) and +[12]) are plotted with bold lines and labeled with CNV name: stable CCF (bold black) is shown. Supplementary Figure S2. CD8+ T cell differentiation subsets and PD1 expression in CD8+ T cells from progressing and non-progressing CLL patients. a CD4/CD8 ratio in progressing (n = 19) and non-progressing patients (n = 10) at diagnosis and progression or non-progression. b Absolute numbers of CD8+ T cell differentiation subsets (naive: CCR7+CD45RA+; central memory, CM: CCR7+CD45RA−; effector memory, EM: CCR7−CD45RA− and EM CD45RA+, EMRA: CCR7−CD45RA+) in progressing (n = 19) and non-progressing patients (n = 10) at diagnosis and progression or non-progression. c Absolute numbers of PD1+CD8+ T cells in progressing (left, n = 19) and non-progressing patients (middle, n = 10) at diagnosis and progression or non-progression. Fold change of PD1+CD8+ T cells between time points comparing progressing and non-progressing patients (right). d Percentage of PD1+CD244+ CD8+ T cells in progressing (left, n = 12) and non-progressing patients (middle, n = 9) at diagnosis and progression or non-progression. Fold change of PD1+CD244+CD8+ T cells between time points comparing progressing and non-progressing patients (right). e Percentage of PD1+ 160+ CD8+ T cells in progressing (left, n = 12) and non-progressing patients (middle, n = 9) at diagnosis and progression or non-progression. Fold change of PD1+CD160+CD8+ T cells between time points comparing progressing and non-progressing patients (right). f ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Additional_file_2_of_Immunological_and_genetic_kinetics_from_diagnosis_to_clinical_progression_in_chronic_lymphocytic_leukemia/14634084 |
| DOI: |
10.6084/m9.figshare.14634084.v1 |
| الاتاحة: |
https://doi.org/10.6084/m9.figshare.14634084.v1 |
| Rights: |
CC BY + CC0 |
| رقم الانضمام: |
edsbas.8970E6DE |
| قاعدة البيانات: |
BASE |