Academic Journal
Contemporary clinical profile and outcome of prosthetic valve endocarditis
| العنوان: | Contemporary clinical profile and outcome of prosthetic valve endocarditis |
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| المؤلفون: | Wang, Andrew, Athan, Eugene, Pappas, Paul A., Fowler, Vance G., Jr., Olaison, Lars, Pare, Carlos, Almirante, Benito, Munoz, Patricia, Rizzi, Marco, Naber, Christoph, Logar, Mateja, Tattevin, Pierre, Iarussi, Diana L., Selton Suty, Christine, Jones, Sandra Braun, Casabe, Jose, Morris, Arthur, Corey, G. Ralph, Cabell, Christopher H., Int Collaboration Endocarditis Pro |
| بيانات النشر: | AMER MEDICAL ASSOC |
| سنة النشر: | 2024 |
| المجموعة: | Pontificia Universidad Católica de Chile: Repositorio UC |
| مصطلحات موضوعية: | INFECTIVE ENDOCARDITIS, MEDICAL PROGRESS, ACQUIRED INFECTIONS, PROPENSITY ANALYSIS, DUKE CRITERIA, RISK-FACTORS, FOLLOW-UP, MORTALITY, DIAGNOSIS, ADULTS, 03 Good Health and Well-being, 03 Salud y bienestar |
| الوصف: | Context Prosthetic valve endocarditis (PVE) is associated with significant mortality and morbidity. The contemporary clinical profile and outcome of PVE are not well defined. ; Objectives To describe the prevalence, clinical characteristics, and outcome of PVE, with attention to health care-associated infection, and to determine prognostic factors associated with in-hospital mortality. ; Design, Setting, and Participants Prospective, observational cohort study conducted at 61 medical centers in 28 countries, including 556 patients with definite PVE as defined by Duke University diagnostic criteria who were enrolled in the International Collaboration on Endocarditis-Prospective Cohort Study from June 2000 to August 2005. ; Main Outcome Measure In-hospital mortality. ; Results Definite PVE was present in 556 (20.1%) of 2670 patients with infective endocarditis. Staphylococcus aureus was the most common causative organism (128 patients [23.0%]), followed by coagulase-negative staphylococci (94 patients [16.9%]). Health care-associated PVE was present in 203 (36.5%) of the overall cohort. Seventy-one percent of health care-associated PVE occurred within the first year of valve implantation, and the majority of cases were diagnosed after the early (60-day) period. Surgery was performed in 272 (48.9%) patients during the index hospitalization. In-hospital death occurred in 127 (22.8%) patients and was predicted by older age, health care associated infection (62/203 [30.5%]; adjusted odds ratio [OR], 1.62; 95% confidence interval [CI], 1.08-2.44; P = .02), S aureus infection (44/128 [34.4%]; adjusted OR, 1.73; 95% CI, 1.01-2.95; P = .05), and complications of PVE, including heart failure (60/183 [32.8%]; adjusted OR, 2.33; 95% CI, 1.62-3.34; P < .001), stroke (34/101 [33.7%]; adjusted OR, 2.25; 95% CI, 1.25-4.03; P = .007), intracardiac abscess (47/144 [32.6%]; adjusted OR, 1.86; 95% CI, 1.10-3.15; P = .02), and persistent bacteremia (27/49 [55.1%]; adjusted OR, 4.29; 95% CI, 1.99-9.22; P < .001). ; Conclusions ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 8 páginas; application/pdf |
| اللغة: | English |
| تدمد: | 0098-7484 |
| Relation: | MEDLINE:17392239; https://doi.org/10.1001/jama.297.12.1354; https://repositorio.uc.cl/handle/11534/79242; WOS:000245212600022 |
| DOI: | 10.1001/jama.297.12.1354 |
| الاتاحة: | https://repositorio.uc.cl/handle/11534/79242 https://doi.org/10.1001/jama.297.12.1354 |
| Rights: | acceso restringido |
| رقم الانضمام: | edsbas.8924E0EA |
| قاعدة البيانات: | BASE |
| تدمد: | 00987484 |
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| DOI: | 10.1001/jama.297.12.1354 |