Academic Journal
Alveolar Macrophages: Adaptation to Their Anatomic Niche during and after Inflammation
| العنوان: | Alveolar Macrophages: Adaptation to Their Anatomic Niche during and after Inflammation |
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| المؤلفون: | Martin, Florian Pierre, Jacqueline, Cédric, Poschmann, Jeremie, Roquilly, Antoine |
| المساهمون: | Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), Thérapeutiques cliniques et expérimentales des infections (EA 3826) (EA 3826), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Institut de transplantation urologie-néphrologie (ITUN), Université de Nantes (UN)-Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes) |
| المصدر: | ISSN: 2073-4409 ; Cells ; https://hal.science/hal-04698937 ; Cells, 2021, 10 (10), pp.2720. ⟨10.3390/cells10102720⟩. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2021 |
| المجموعة: | Université de Nantes: HAL-UNIV-NANTES |
| مصطلحات موضوعية: | alveolar niche, inflammatory monocytes, lung microenvironment, pneumonia, resident alveolar macrophages, trained immunity, MESH: Adaptation, Physiological, MESH: Fibrosis, MESH: Homeostasis, MESH: Humans, MESH: Infections, MESH: Inflammation, MESH: Macrophages, Alveolar, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; At the early stages of life development, alveoli are colonized by embryonic macrophages, which become resident alveolar macrophages (ResAM) and self-sustain by local division. Genetic and epigenetic signatures and, to some extent, the functions of ResAM are dictated by the lung microenvironment, which uses cytokines, ligand-receptor interactions, and stroma cells to orchestrate lung homeostasis. In resting conditions, the lung microenvironment induces in ResAM a tolerogenic programming that prevents unnecessary and potentially harmful inflammation responses to the foreign bodies, which continuously challenge the airways. Throughout life, any episode of acute inflammation, pneumonia being likely the most frequent cause, depletes the pool of ResAM, leaving space for the recruitment of inflammatory monocytes that locally develop in monocyte-derived alveolar macrophages (InfAM). During lung infection, the local microenvironment induces a temporary inflammatory signature to the recruited InfAM to handle the tissue injury and eliminate the pathogens. After a few days, the recruited InfAM, which locally self-sustain and develop as new ResAM, gain profibrotic functions required for tissue healing. After the complete resolution of the infectious episode, the functional programming of both embryonic and monocyte-derived ResAM remains altered for months and possibly for the entire life. Adult lungs thus contain a wide diversity of ResAM since every infection brings new waves of InfAM which fill the room left open by the inflammatory process. The memory of these innate cells called trained immunity constitutes an immunologic scar left by inflammation, notably pneumonia. This memory of ResAM has advantages and drawbacks. In some cases, lung-trained immunity offers better defense capacities against autoimmune disorders and the long-term risk of infection. At the opposite, it can perpetuate a harmful process and lead to a pathological state, as is the case among critically ill patients who have immune ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34685700; hal-04698937; https://hal.science/hal-04698937; https://hal.science/hal-04698937v1/document; https://hal.science/hal-04698937v1/file/cells-10-02720.pdf; PUBMED: 34685700; PUBMEDCENTRAL: PMC8534884 |
| DOI: | 10.3390/cells10102720 |
| الاتاحة: | https://hal.science/hal-04698937 https://hal.science/hal-04698937v1/document https://hal.science/hal-04698937v1/file/cells-10-02720.pdf https://doi.org/10.3390/cells10102720 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.8912A680 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cells10102720 |
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