التفاصيل البيبلوغرافية
| العنوان: |
Role of cholecystokinin as a regulator of solid and liquid gastric emptying in humans. |
| المؤلفون: |
Borovicka, J., Kreiss, C., Asal, K., Remy, B., Mettraux, C., Wells, A., Read, N.W., Jansen, J.B., D'Amato, M., Delaloye, A.B., Fried, M., Schwizer, W. |
| المصدر: |
American Journal of Physiology, vol. 271, no. 3, pp. G448-G453 |
| سنة النشر: |
1996 |
| المجموعة: |
Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: |
Adult, Cholecystokinin/physiology, Female, Food, Gamma Cameras, Gastric Emptying/physiology, Humans, Male, Middle Aged |
| الوصف: |
The role of endogenous cholecystokinin (CCK) in the regulation of gastric emptying remains controversial. We therefore studied the effect of the CCK-A receptor antagonist loxiglumide on gastric emptying of a high-caloric solid-liquid meal in humans. Gastric emptying was assessed in eight volunteers using intravenous loxiglumide or placebo in a randomized double-blind order. Subjects were studied by a dual-headed gamma camera after ingestion of a pancake (570 kcal) labeled with 99mTc-sulfur colloid and 500 ml 10% glucose containing 111In-diethylenetriamine pentaacetic acid. Plasma CCK was measured by a specific radioimmunoassay. Loxiglumide markedly accelerated gastric emptying of both phases of the meal. The lag period was shortened by 26% (P < 0.03); the area under the emptying curve and half-emptying time of solid emptying were lowered by 19 and 24% (P < 0.02) and of liquid emptying by 18 and 24% (P < 0.04), respectively. Plasma CCK levels were higher during infusion of loxiglumide compared with placebo (P < 0.02). These data demonstrate that post-prandially released CCK is a major regulator of gastric emptying of physiological meals containing both solid and liquid components. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/8843769; info:eu-repo/semantics/altIdentifier/pissn/0002-9513; https://serval.unil.ch/notice/serval:BIB_5771 |
| الاتاحة: |
https://serval.unil.ch/notice/serval:BIB_5771 |
| رقم الانضمام: |
edsbas.88FCA296 |
| قاعدة البيانات: |
BASE |