Academic Journal
Eosinophils support adipocyte maturation and promote glucose tolerance in obesity
| العنوان: | Eosinophils support adipocyte maturation and promote glucose tolerance in obesity |
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| المؤلفون: | Lee, Eun-Hui, Itan, Michal, Jang, Jinsun, Gu, Hyeon-Jung, Rozenberg, Perri, Mingler, Melissa K., Wen, Ting, Yoon, Jiyoung, Park, Shi-Young, Roh, Joo Young, Choi, Cheol Soo, Park, Woo-Jae, Munitz, Ariel, Jung, YunJae |
| المساهمون: | Center for Women In Science, Engineering and Technology (WISET) Grant of Korea, National Research Foundation of Korea, Korea Health Industry Development Institute |
| المصدر: | Scientific Reports ; volume 8, issue 1 ; ISSN 2045-2322 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2018 |
| الوصف: | Accumulating data have indicated a fundamental role of eosinophils in regulating adipose tissue homeostasis. Here, we performed whole-genome RNA sequencing of the small intestinal tract, which suggested the presence of impaired lipid metabolism in eosinophil-deficient ΔdblGATA mice. ΔdblGATA mice fed a high-fat diet (HFD) showed reduced body fat mass, impaired enlargement of adipocytes, decreased expression of adipogenic genes, and developed glucose intolerance. HFD induced accumulation of eosinophils in the perigonadal white adipose tissue. Concordantly, adipocyte-differentiated 3T3-L1 cells promoted the migration of eosinophils through the expression of CCL11 (eotaxin-1) and likely promoted their survival through the expression of interleukin (IL)-3, IL-5, and granulocyte-macrophage colony-stimulating factor. HFD-fed ΔdblGATA mice showed increased infiltration of macrophages, CD4 + T-cells, and B-cells, increased expression of interferon-γ, and decreased expression of IL-4 and IL-13 in white adipose tissue. Interferon-γ treatment significantly decreased lipid deposition in adipocyte-differentiated 3T3-L1 cells, while IL-4 treatment promoted lipid accumulation. Notably, HFD-fed ΔdblGATA mice showed increased lipid storage in the liver as compared with wild-type mice. We propose that obesity promotes the infiltration of eosinophils into adipose tissue that subsequently contribute to the metabolic homeostasis by promoting adipocyte maturation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41598-018-28371-4 |
| الاتاحة: | http://dx.doi.org/10.1038/s41598-018-28371-4 https://www.nature.com/articles/s41598-018-28371-4.pdf https://www.nature.com/articles/s41598-018-28371-4 |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.88E58227 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-018-28371-4 |
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