Academic Journal
Ischemic Cardiomyopathy and Heart Failure After Acute Myocardial Infarction
| العنوان: | Ischemic Cardiomyopathy and Heart Failure After Acute Myocardial Infarction |
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| المؤلفون: | Del Buono, Marco Giuseppe, Moroni, Francesco, Montone, Rocco Antonio, Azzalini, Lorenzo, Sanna, Tommaso, Abbate, Antonio |
| المساهمون: | Università Cattolica del Sacro Cuore |
| المصدر: | Current Cardiology Reports ; volume 24, issue 10, page 1505-1515 ; ISSN 1523-3782 1534-3170 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2022 |
| الوصف: | Purpose of Review Ischemic cardiomyopathy refers to systolic left ventricular dysfunction in the setting of obstructive coronary artery disease and represents the most common cause of heart failure worldwide. It is often the combination of an irreversible loss of viable mass following an acute myocardial infarction (AMI) with a dysfunctional, but still viable, myocardium in the context of a chronically reduced myocardial blood flow and reduced coronary reserve. Medical treatments aiming at modulating neurohumoral response and restoring blood flow to the ischemic cardiomyocytes were shown to dramatically abate the occurrence of ventricular dysfunction and adverse remodeling in ischemic cardiomyopathy. Recent Findings Novel therapeutic approaches, such as mechanical unloading and modulation of the inflammatory response, appear to be promising. Furthermore, the understanding of the mechanisms by which, despite optimal treatment, heart failure ensues after AMI, with or without adverse remodeling and systolic dysfunction, is a critical step in the search for novel ways to tackle heart failure risk beyond preservation of left ventricular volumes and systolic function. Summary In this review article, we explore the principal pathophysiological mechanisms and pathways of heart failure in ischemic cardiomyopathy, therapeutic opportunities, and knowledge gaps in this area. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1007/s11886-022-01766-6 |
| DOI: | 10.1007/s11886-022-01766-6.pdf |
| DOI: | 10.1007/s11886-022-01766-6/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1007/s11886-022-01766-6 https://link.springer.com/content/pdf/10.1007/s11886-022-01766-6.pdf https://link.springer.com/article/10.1007/s11886-022-01766-6/fulltext.html |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.88D9C4D3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s11886-022-01766-6 |
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