Academic Journal
Short-Term Environmental Enrichment is a Stronger Modulator of Brain Glial Cells and Cervical Lymph Node T Cell Subtypes than Exercise or Combined Exercise and Enrichment
| العنوان: | Short-Term Environmental Enrichment is a Stronger Modulator of Brain Glial Cells and Cervical Lymph Node T Cell Subtypes than Exercise or Combined Exercise and Enrichment |
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| المؤلفون: | Singhal, Gaurav, Morgan, Julie, Corrigan, Frances, Toben, Catherine, Jawahar, Magdalene Catharine, Jaehne, Emily, Manavis, Jim, Hannan, Anthony, Baune, Bernhard T |
| المصدر: | http://lobid.org/resources/99370673819506441#!, 41(3):469-486. |
| سنة النشر: | 2020 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Mice, Inbred C57BL [MeSH], T-Lymphocytes/immunology [MeSH], Environmental enrichment, Lymph Nodes/cytology [MeSH], Microfilament Proteins/metabolism [MeSH], Microglia, Glial Fibrillary Acidic Protein/metabolism [MeSH], Brain/cytology [MeSH], Astrocytes, Dentate Gyrus/metabolism [MeSH], Animals [MeSH], Astrocytes/cytology [MeSH], Aging, Immunophenotyping [MeSH], Cervical Vertebrae/cytology [MeSH], Biomarkers/metabolism [MeSH], Neuroglia/cytology [MeSH], Physical exercise, Calcium-Binding Proteins/metabolism [MeSH], Original Research, Environment [MeSH], Physical Conditioning, Animal [MeSH], T cells, Antigens, CD/metabolism [MeSH] |
| الوصف: | Physical exercise (PE) and environmental enrichment (EE) can modulate immunity. However, the differential effects of short-term PE, EE, and PE + EE on neuroimmune mechanisms during normal aging has not been elucidated. Hence, a cohort of 3-, 8-, and 13-month-old immunologically unchallenged C57BL/6 wild-type mice were randomly assigned to either Control, PE, EE, or PE + EE groups and provided with either no treatment, a running wheel, a variety of plastic and wooden objects alone or in combination with a running wheel for seven weeks, respectively. Immunohistochemistry and 8-color flow cytometry were used to determine the numbers of dentate gyrus glial cells, and the proportions of CD4 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://repository.publisso.de/resource/frl:6468254; https://doi.org/10.1007/s10571-020-00862-x; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920895/ |
| DOI: | 10.1007/s10571-020-00862-x |
| الاتاحة: | https://repository.publisso.de/resource/frl:6468254 https://doi.org/10.1007/s10571-020-00862-x https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920895/ |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.88ABDC9C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s10571-020-00862-x |
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