التفاصيل البيبلوغرافية
| العنوان: |
Lactobacillus rhamnosus LRa05 Ameliorate Hyperglycemia through a Regulating Glucagon-Mediated Signaling Pathway and Gut Microbiota in Type 2 Diabetic Mice |
| المؤلفون: |
Tao Wu (16763), Yongli Zhang (274182), Wen Li (143214), Yunjiao Zhao (11221373), Hairong Long (11221376), Esther Mwizerwa Muhindo (11221379), Rui Liu (54031), Wenjie Sui (2272876), Qian Li (114642), Min Zhang (111999) |
| سنة النشر: |
1753 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biochemistry, Microbiology, Genetics, Physiology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, hepatic oxidative stress, LRa 05 attenuated insulin resistance, Type 2 Diabetic Mice, gut microbiota, Regulating Glucagon-Mediated Signal., Lactobacillus rhamnosus LRa 05, Lactobacillus rhamnosus LRa 05 Amel., disorder glucose metabolism, LRa 05, fasting blood glucose levels, type 2 diabetes mellitus, T 2DM mice, CFU |
| الوصف: |
In this study, we aimed to explore the antidiabetic effects of Lactobacillus rhamnosus LRa05 on glucose metabolism and gut microbiota in type 2 diabetes mellitus (T2DM) mice. Our data indicated that the fasting blood glucose levels were reduced by 53.5% after treatment with LRa05 at a dose of 10 9 CFU·day –1 . Meanwhile, LRa05 attenuated insulin resistance, relieved hepatic oxidative stress, and alleviated metabolic lipopolysaccharide-related inflammation in T2DM mice. LRa05 promoted the expression of glucose transporter 2, while it inhibited the expression of glucagon receptor, glucose-6-phosphatase, cellular adenosine-3′-5′-cyclic monophosphate-dependent protein kinase, and phosphoenolpyruvate carboxykinase in diabetic mice. Meanwhile, LRa05 reshaped gut microbiota, resulting in increased short-chain fatty acid bacteria (Alloprevotella and Bacteroides) and decreased proinflammatory bacteria (Odoribacter and Mucispirillum). Thus, LRa05 may be used as a functional food supplement for modulating the disorder glucose metabolism and gut microbiota in T2DM. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/_i_Lactobacillus_rhamnosus_i_LRa05_Ameliorate_Hyperglycemia_through_a_Regulating_Glucagon-Mediated_Signaling_Pathway_and_Gut_Microbiota_in_Type_2_Diabetic_Mice/15095825 |
| DOI: |
10.1021/acs.jafc.1c02925.s001 |
| الاتاحة: |
https://doi.org/10.1021/acs.jafc.1c02925.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.88A9F817 |
| قاعدة البيانات: |
BASE |