التفاصيل البيبلوغرافية
| العنوان: |
Table2_Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1.XLSX |
| المؤلفون: |
Katrin Hipke, Bettina Pitter, Alexander Hruscha, Frauke van Bebber, Miha Modic, Vikas Bansal, Sebastian A. Lewandowski, Denise Orozco, Dieter Edbauer, Stefan Bonn, Christian Haass, Ulrich Pohl, Eloi Montanez, Bettina Schmid |
| سنة النشر: |
2023 |
| المجموعة: |
Frontiers: Figshare |
| مصطلحات موضوعية: |
Cell Biology, Marine Biology, Cell Development, Proliferation and Death, Cell Metabolism, Cell Neurochemistry, Cellular Interactions (incl. Adhesion, Matrix, Cell Wall), TDP-43, angiogenesis, neurodegeneration, zebrafish, ALS |
| الوصف: |
Aggregation of the Tar DNA-binding protein of 43 kDa (TDP-43) is a pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia and likely contributes to disease by loss of nuclear function. Analysis of TDP-43 function in knockout zebrafish identified an endothelial directional migration and hypersprouting phenotype during development prior lethality. In human umbilical vein cells (HUVEC) the loss of TDP-43 leads to hyperbranching. We identified elevated expression of FIBRONECTIN 1 (FN1), the VASCULAR CELL ADHESION MOLECULE 1 (VCAM1), as well as their receptor INTEGRIN α4β1 (ITGA4B1) in HUVEC cells. Importantly, reducing the levels of ITGA4, FN1, and VCAM1 homologues in the TDP-43 loss-of-function zebrafish rescues the angiogenic defects indicating the conservation of human and zebrafish TDP-43 function during angiogenesis. Our study identifies a novel pathway regulated by TDP-43 important for angiogenesis during development. |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/dataset/Table2_Loss_of_TDP-43_causes_ectopic_endothelial_sprouting_and_migration_defects_through_increased_fibronectin_vcam_1_and_integrin_4_1_XLSX/23505495 |
| DOI: |
10.3389/fcell.2023.1169962.s009 |
| الاتاحة: |
https://doi.org/10.3389/fcell.2023.1169962.s009
https://figshare.com/articles/dataset/Table2_Loss_of_TDP-43_causes_ectopic_endothelial_sprouting_and_migration_defects_through_increased_fibronectin_vcam_1_and_integrin_4_1_XLSX/23505495 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.886F8671 |
| قاعدة البيانات: |
BASE |