Academic Journal
Multispectral optoacoustic tomography of the human intestine – temporal precision and the influence of postprandial gastrointestinal blood flow
| العنوان: | Multispectral optoacoustic tomography of the human intestine – temporal precision and the influence of postprandial gastrointestinal blood flow |
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| المؤلفون: | Lars-Philip Paulus, Alexandra L. Wagner, Adrian Buehler, Roman Raming, Jörg Jüngert, David Simon, Koray Tascilar, Alexander Schnell, Josefine Günther, Ulrich Rother, Werner Lang, André Hoerning, Georg Schett, Markus F. Neurath, Joachim Woelfle, Maximilian J. Waldner, Ferdinand Knieling, Adrian P. Regensburger |
| المصدر: | Photoacoustics, Vol 30, Iss , Pp 100457- (2023) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Optoacoustic, Photoacoustic, Multispectral optoacoustic imaging, Inflammatory bowel disease, Gut, Reliability, Physics, QC1-999, Acoustics. Sound, QC221-246, Optics. Light, QC350-467 |
| الوصف: | Multispectral optoacoustic tomography (MSOT) holds great promise as a non-invasive diagnostic tool for inflammatory bowel diseases. Yet, reliability and the impact of physiological processes during fasting and after food intake on optoacoustic signals have not been studied. In the present investigator initiated trial (NCT05160077) the intestines of ten healthy subjects were examined by MSOT at eight timepoints on two days, one fasting and one after food intake. While within-timepoint and within-day reproducibility were good for single wavelength 800 nm and total hemoglobin (ICC 0.722 to 0.956), between-day reproducibility was inferior (ICC −0.137 to 0.438). However, temporal variability was smaller than variation between individuals (coefficients of variation 8.9% − 33.7% vs. 17.0% − 48.5%). After food intake and consecutive increased intestinal circulation, indicated by reduced resistance index of simultaneous Doppler ultrasound, optoacoustic signals did not alter significantly. In summary, this study demonstrates high reliability and temporal stability of MSOT for imaging the human intestine during fasting and after food intake. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2213-5979 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2213597923000101; https://doaj.org/toc/2213-5979; https://doaj.org/article/c0323eaab7844ab18cf4932b02701f7b |
| DOI: | 10.1016/j.pacs.2023.100457 |
| الاتاحة: | https://doi.org/10.1016/j.pacs.2023.100457 https://doaj.org/article/c0323eaab7844ab18cf4932b02701f7b |
| رقم الانضمام: | edsbas.886456EE |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 22135979 |
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| DOI: | 10.1016/j.pacs.2023.100457 |