Academic Journal
Targeting Common but Complex Proteoglycans on Breast Cancer Cells and Stem Cells Using Evolutionary Refined Malaria Proteins
| العنوان: | Targeting Common but Complex Proteoglycans on Breast Cancer Cells and Stem Cells Using Evolutionary Refined Malaria Proteins |
|---|---|
| المؤلفون: | Salanti, Ali |
| المساهمون: | COPENHAGEN UNIV (DENMARK) |
| المصدر: | DTIC |
| سنة النشر: | 2014 |
| المجموعة: | Defense Technical Information Center: DTIC Technical Reports database |
| مصطلحات موضوعية: | Biochemistry, Anatomy and Physiology, Medicine and Medical Research, BREAST CANCER, GLYCOSIDASES, PROTEINS(CONJUGATED), STEM CELLS, BIOASSAY, BIOPSY, BLOOD CELLS, CLINICAL MEDICINE, ESCHERICHIA COLI, IN VITRO ANALYSIS, MALARIA, MAMMARY GLANDS, METASTASIS, MUTATIONS, ONCOLOGY, PARASITOLOGY, RECEPTOR SITES(PHYSIOLOGY), TISSUES(BIOLOGY), TREATMENT, RECOMBINANT PROTEINS, DRUG CONJUGATE, MALARIA PROTEINS |
| الوصف: | In the past year of the project we have successfully produced recombinant VAR2CSA that binds with high affinity and high specificity to breast cancer cells and breast cancer tissue biopsies. We have demonstrated that the protein binds to distinct secondary modified proteoglycans exclusively present on breast cancer cells and that targeting these with recombinant VAR2CSA interferes with key functions of the cancer cell like growth, migration and invasion. ; The original document contains color images. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://www.dtic.mil/docs/citations/ADA616972 |
| الاتاحة: | http://www.dtic.mil/docs/citations/ADA616972 http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA616972 |
| Rights: | Approved for public release; distribution is unlimited. |
| رقم الانضمام: | edsbas.8861EA46 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |