Academic Journal
Immunohistochemical expression of HGF, c-MET and transcription factor STAT3 in colorectal tumors
| العنوان: | Immunohistochemical expression of HGF, c-MET and transcription factor STAT3 in colorectal tumors |
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| المؤلفون: | M Trovato, E Vitarelli, M Grosso, S Alesci, S Benvenga, F Trimarchi, G Barresi |
| المصدر: | European Journal of Histochemistry, Vol 48, Iss 3 (2009) |
| بيانات النشر: | PAGEPress Publications |
| سنة النشر: | 2009 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Biology (General), QH301-705.5 |
| الوصف: | By immunohistochemistry, we have investigated the expression of hepatocyte growth factor (HGF), HGF-R or c-met and the transcritor factor STAT3 in a series of 80 colorectal tumours (40 adenomas and 40 adenocarcinomas). The expression of HGF, c-met and STAT3 was revealed in 40/40 (100%) of adenomas and in 26/40 (65%) of adenocarcinomas; the remaining 14/40 (35%) carcinomas expressed cmet but failed to express HGF and STAT3. Positive immunoreaction score was defined through the number of stained cells: low (1-10%), moderate (11-50%) and high (>51%). In adenomas, the HGF immunoreaction was high in 33 (82.5%) and moderate in 7 (17.5%); the c-met staining was high in 3 (7.5%) and moderate in 37 (92.5%); and the STAT3 reactivity was high in 25 (62.5%) and moderate in 15(37.5%). In carcinomas, the HGF immunoreaction was moderate in 21 (80.7%) and low in 5 (19.2%); the c-met staining was high in 14 (35%), moderate in 25 (62.5) and low in 1 (2.5%); and the STAT3 reactivity was moderate in 17 (65.3%) and low in 9 (34.6%). In both type of lesions, HGF and c-met showed a membranous and cytoplasmic location. In adenomas, STAT3 was detected in cytoplasm and nucleus and in carcinomas it was limited to cytoplasm. While the HGF/c-met/STAT3 expression in adenomas was significantly different from carcinomas (c2 = 17, p < 0.0001), no correlation was found among HGF, c-met, or STAT3 immunostaining with histotype or degree of dysplasia in adenomas and the same for histotype, grading or staging in carcinomas. These features, suggesting a role of the HGF/c-met/STAT3 signal in colon tumorigenesis, indicate that a reduced expression of HGF and c-met is associated to progression of adenoma into carcinoma. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1121-760X 2038-8306 |
| Relation: | https://www.ejh.it/index.php/ejh/article/view/898; https://doaj.org/toc/1121-760X; https://doaj.org/toc/2038-8306; https://doaj.org/article/4a99ceae0b1c45f2ab7a6b4a950ab279 |
| DOI: | 10.4081/898 |
| الاتاحة: | https://doi.org/10.4081/898 https://doaj.org/article/4a99ceae0b1c45f2ab7a6b4a950ab279 |
| رقم الانضمام: | edsbas.8855090C |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 1121760X 20388306 |
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| DOI: | 10.4081/898 |