التفاصيل البيبلوغرافية
| العنوان: |
Effects of childhood trauma on BDNF and TBARS during crack-cocaine withdrawal |
| المؤلفون: |
Sordi, Anne Orgler, Diemen, Lisia von, Schuch, Silvia Bassani, Ornell, Felipe, Kapczinski, Flávio Pereira, Pfaffenseller, Bianca, Gubert, Carolina de Moura, Aguiar, Bianca Wollenhaupt de, Salum Junior, Giovanni Abrahão, Pechansky, Flavio |
| سنة النشر: |
2020 |
| المجموعة: |
Universidade Federal do Rio Grande do Sul (UFRGS): Lume |
| مصطلحات موضوعية: |
Estresse oxidativo, Cocaína, Trauma psicológico, Experiências adversas da infância, Transtornos relacionados ao uso de substâncias, Fator neurotrófico derivado do encéfalo, Childhood trauma, Cocaine, Drug abuse, BDNF, Oxidative stress |
| الوصف: |
Objective: To evaluate the association between childhood trauma (CT) and serum levels of brainderived neurotrophic factor (BDNF) and thiobarbituric acid-reactive substances (TBARS) during crackcocaine withdrawal. Method: Thirty-three male crack-cocaine users were recruited at admission to a public addiction treatment unit. Serum BDNF and TBARS levels were evaluated at intake and discharge. Information about drug use was assessed by the Addiction Severity Index-6th Version (ASI-6); CT was reported throughout the Childhood Trauma Questionnaire (CTQ). CTQ scores were calculated based on a latent analysis model that divided the sample into low-, medium-, and high-level trauma groups. Results: There was a significant increase in BDNF levels from admission to discharge, which did not differ across CT subgroups. For TBARS levels, we found a significant time vs. trauma interaction (F2,28 = 6.357, p = 0.005,Zp 2 = 0.312). In participants with low trauma level, TBARS decreased, while in those with a high trauma level, TBARS increased during early withdrawal. Conclusion: TBARS levels showed opposite patterns of change in crack-cocaine withdrawal according to baseline CT. These results suggest that CT could be associated with more severe neurological impairment during withdrawal. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
1516-4446 |
| Relation: |
Revista brasileira de psiquiatria. São Paulo. Vol. 42, n.2 (2020), p. 214-217; http://hdl.handle.net/10183/215188; 001118365 |
| الاتاحة: |
http://hdl.handle.net/10183/215188 |
| Rights: |
Open Access |
| رقم الانضمام: |
edsbas.8839807B |
| قاعدة البيانات: |
BASE |
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