Academic Journal
A Novel 4H-Chromen-4-One Derivative from Marine Streptomyces ovatisporus S4702T as Potential Antibacterial and Anti-Cancer Agent
| العنوان: | A Novel 4H-Chromen-4-One Derivative from Marine Streptomyces ovatisporus S4702T as Potential Antibacterial and Anti-Cancer Agent |
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| المؤلفون: | Kurt-Kizildogan, Aslihan, Akarsu, Neslihan, Otur, Cigdem, Kivrak, Arif, Aslan-Ertas, Nevroz, Arslan, Sevki, Konus, Metin, Yilmaz, Can, Cetin, Dogan, Mutlu, Dogukan, Sahin, Nevzat, Topal, Tufan |
| بيانات النشر: | Bentham Science Publ Ltd |
| سنة النشر: | 2022 |
| المجموعة: | Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi |
| مصطلحات موضوعية: | 4H-chromen-4-one, Streptomyces ovatisporus S4702 T, antibacterial activity, NMR, LC-MS, MS, cytotoxicity, Secondary Metabolites |
| الوصف: | Background: Marine actinomycetes are among indispensable sources of natural bioactive compounds with unique antimicrobial and anti-cancer activities. Objective: Herein, it was aimed to elucidate the bioactive potential of a marine-derived Streptomyces ovatisporus Methods: Streptomyces ovatisporus S4702T was cultured in N-Z Amine broth, and extraction was carried out using different organic solvents. Bioassay-guided purification was followed by chemical characterization using NMR and LC-MS/MS. The compound was then evaluated for its antibacterial, antioxidant and cytotoxic activities. Results: Etyl acetate extracts gave the highest antibacterial activity, and chemical characterization of this extract indicated the formula as C15H29O5N3 and the corresponding possible molecular structure as 4H-chromen-4-one derivative. It was found highly potent against Bacillus subtilis ATCC 6633 (MIC: 0.25 mu g ml-1) and Micrococcus luteus ATCC 9341 (MBC: 0.5 mu g ml-1). It has no remarkable antioxidant activity, but a higher EC50 value and less cytotoxicity against normal cells. The EC50 values of this chromen derivative were found as 9.68 mu g ml-1 for human colon carcinoma, 9.93 mu g ml-1 for human prostate adenocarcinoma and 25.5 mu g ml-1 for human embryonic kidney cells. Conclusion: Overall, the presented 4H-chromen-4-one derivative is a remarkable bioactive compound with potent antibacterial and cytotoxic activity. With its high bioactive potential, it is proposed as a good candidate in medicine. ; This study was supported by Ondokuz Mays University Research Fund [grant number: PYO.ZRT.1904.17.053] . The reactant and reagents for MTT and antioxidant assays were funded by Pamukkale University (PAU-BAP-2018-KRM-011) and Yuzuncu Yil University (YYU BAP Project No:2015-FBE-YL365) , respectively. ; Ondokuz Mays University Research Fund [PYO.ZRT.1904.17.053]; Pamukkale University [PAU-BAP-2018-KRM-011]; Yuzuncu Yil University (YYU BAP Project) [2015-FBE-YL365] |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | Anti-Cancer Agents In Medicinal Chemistry; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.2174/1871520621666210311085748; https://hdl.handle.net/11499/46642; 22; 362; 370; WOS:000754261000006 |
| DOI: | 10.2174/1871520621666210311085748 |
| الاتاحة: | https://hdl.handle.net/11499/46642 https://doi.org/10.2174/1871520621666210311085748 |
| Rights: | none |
| رقم الانضمام: | edsbas.880E61A6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.2174/1871520621666210311085748 |
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