Academic Journal
Bidirectional modulation of synaptic transmission by insulin-like growth factor-I
| العنوان: | Bidirectional modulation of synaptic transmission by insulin-like growth factor-I |
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| المؤلفون: | José Antonio Noriega-Prieto, Laura Eva Maglio, Paloma Perez-Domper, José Carlos Dávila, Antonia Gutiérrez, Ignacio Torres-Alemán, David Fernández de Sevilla |
| المصدر: | Frontiers in Cellular Neuroscience, Vol 18 (2024) |
| بيانات النشر: | Frontiers Media S.A. |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | insulin-like growth factor-I, LTP, LTD, spike-timing dependent plasticity, Hebbian plasticity, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: | Insulin-like growth factor-I (IGF-I) plays a key role in the modulation of synaptic plasticity and is an essential factor in learning and memory processes. However, during aging, IGF-I levels are decreased, and the effect of this decrease in the induction of synaptic plasticity remains unknown. Here we show that the induction of N-methyl-D-aspartate receptor (NMDAR)-dependent long-term potentiation (LTP) at layer 2/3 pyramidal neurons (PNs) of the mouse barrel cortex is favored or prevented by IGF-I (10 nM) or IGF-I (7 nM), respectively, when IGF-I is applied 1 h before the induction of Hebbian LTP. Analyzing the cellular basis of this bidirectional control of synaptic plasticity, we observed that while 10 nM IGF-I generates LTP (LTPIGF-I) of the post-synaptic potentials (PSPs) by inducing long-term depression (LTD) of the inhibitory post-synaptic currents (IPSCs), 7 nM IGF-I generates LTD of the PSPs (LTDIGF-I) by inducing LTD of the excitatory post-synaptic currents (EPSCs). This bidirectional effect of IGF-I is supported by the observation of IGF-IR immunoreactivity at both excitatory and inhibitory synapses. Therefore, IGF-I controls the induction of Hebbian NMDAR-dependent plasticity depending on its concentration, revealing novel cellular mechanisms of IGF-I on synaptic plasticity and in the learning and memory machinery of the brain. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1662-5102 |
| Relation: | https://www.frontiersin.org/articles/10.3389/fncel.2024.1390663/full; https://doaj.org/toc/1662-5102; https://doaj.org/article/a49a8675cbde4d53851bc82568d2d635 |
| DOI: | 10.3389/fncel.2024.1390663 |
| الاتاحة: | https://doi.org/10.3389/fncel.2024.1390663 https://doaj.org/article/a49a8675cbde4d53851bc82568d2d635 |
| رقم الانضمام: | edsbas.87C6A886 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16625102 |
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| DOI: | 10.3389/fncel.2024.1390663 |