Academic Journal
A New Strategy for the Treatment of Patients With Prolonged Impairment of Consciousness Using Xenon. Prospective Pilot Study ; Новая стратегия лечения пациентов с длительным нарушением сознания с применением ксенона. Проспективное пилотное исследование
| العنوان: | A New Strategy for the Treatment of Patients With Prolonged Impairment of Consciousness Using Xenon. Prospective Pilot Study ; Новая стратегия лечения пациентов с длительным нарушением сознания с применением ксенона. Проспективное пилотное исследование |
|---|---|
| المؤلفون: | A. I. Shpichko, A. N. Kuzovlev, R. A. Cherpakov, N. P. Shpichko, O. A. Grebenchikov, A. K. Yevseyev, A. K. Shabanov, S. S. Petrikov, А. И. Шпичко, А. Н. Кузовлев, Р. А. Черпаков, Н. П. Шпичко, О. А. Гребенчиков, А. К. Евсеев, А. К. Шабанов, С. С. Петриков |
| المصدر: | Russian Sklifosovsky Journal "Emergency Medical Care"; Том 11, № 4 (2022); 592-599 ; Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь»; Том 11, № 4 (2022); 592-599 ; 2541-8017 ; 2223-9022 |
| بيانات النشر: | “N.V. Sklifosovsky Research Institute for Emergency Medicine” |
| سنة النشر: | 2023 |
| المجموعة: | Sklifosovsky Journal "Emergency Medical Care" / Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь» |
| مصطلحات موضوعية: | реабилитация, traumatic brain injury, impaired consciousness, neuroinflammation, neuroprotection, rehabilitation, черепно-мозговая травма, нарушение сознания, нейровоспаление, нейропротекция |
| الوصف: | In addition to high mortality, craniocerebral injuries have another danger, a long rehabilitation period and a high percentage of disability with the development of cognitive impairment. This is primarily associated with the processes of neuroinflammation, which development, according to recent data, leads to a long-term impairment of consciousness. The anti-inflammatory effects of xenon inhalation anesthetic, which have been repeatedly shown in previous studies, have the potential to beneficially affect the level of consciousness in these patients by targeting key links of neuroinflammation.AIM OF STUDY To evaluate the effect of oxygen-xenon mixture inhalation on the level of consciousness recovery and the severity of spastic activity in patients after traumatic brain injury.MATERIAL AND METHODS A prospective randomized clinical trial of the effect of inhaled xenon sedation on the level of consciousness and spastic activity in patients with post-coma long-term impairment of consciousness was conducted. Patients were randomized into two equal groups. In group I (comparisons, n=15) (in addition to the standard treatment after a traumatic brain injury), each patient included in the study underwent 7 sessions of inhalation of an air-oxygen mixture with an oxygen content of at least 30 vol% for 30 minutes. In group II (study, n=15) (in addition to standard treatment), each patient included in the study inhaled an oxygen-xenon gas mixture (xenon content 30 vol%) for 7 days 1 time per day. Before and after the course of treatment (on the 7th day), patients were assessed using the CRS-R scale and the modified Ashworth scale.RESULTS The final evaluation included 12 patients from the comparison group and 12 patients from the study group. Three patients were excluded from each group as a result of critical incidents not related to the type of the therapy. In the comparison group on the 7th day, the level of consciousness was score 9 [7; 11] and did not differ statistically significantly from the baseline (p>0.05), ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Russian |
| Relation: | https://www.jnmp.ru/jour/article/view/1516/1235; Сабиров Д.М., Хашимова Д.Х., Акалаев Р.Н., Красненкова М.Б., Росстальная А.Л., Залялова З.С. и др. Анализ причин летальности больных с тяжелыми черепно-мозговыми травмами. Вестник экстренной медицины. 2011; 4:5–9; Capizzi A, Woo J, Verduzco-Gutierrez M. Traumatic Brain Injury: An Overview of Epidemiology, Pathophysiology, and Medical Management. Med Clin North Am. 2020; 104(2):213–238. PMID: 32035565. https://doi.org/10.1016/j.mcna.2019.11.001.; Galgano M, Toshkezi G, Qiu X, Russell T, Chin L, Zhao LR. Traumatic Brain Injury: Current Treatment Strategies and Future Endeavors. Cell Transplant. 2017;26(7):1118–1130. PMID: 28933211. https://doi.org/10.1177/0963689717714102.; Pavlovic D, Pekic S, Stojanovic M, Popovic V. Traumatic brain injury: neuropathological, neurocognitive and neurobehavioral sequelae. Pituitary. 2019; 22(3):270–282. PMID: 30929221. https://doi.org/10.1007/s11102-019-00957-9.; Corps KN, Roth TL, McGavern DB. Inflammation and neuroprotection in traumatic brain injury. JAMA Neurol. 2015; 72(3):355–362. PMID: 25599342. https://doi.org/10.1001/jamaneurol.2014.3558; Jo M, Kim JH, Song GJ, Seo M, Hwang EM, Suk K. Astrocytic Orosomucoid2 Modulates Microglial Activation and Neuroinflammation. J Neurosci. 2017;37(11):2878–2894. PMID: 28193696. https://doi.org/10.1523/JNEUROSCI.2534-16.2017.; Maze M, Laitio T. Neuroprotective Properties of Xenon. Mol Neurobiol. 2020; 57(1):118–124. PMID: 31758401. https://doi.org/10.1007/s12035019-01761-z; Licastro F, Hrelia S, Porcellini E, Malaguti M, Di Stefano C, Angeloni C, et al. Peripheral Inflammatory Markers and Antioxidant Response during the Post-Acute and Chronic Phase after Severe Traumatic Brain Injury. Front Neurol. 2016; 7:189. PMID: 27853449. https://doi.org/10.3389/fneur.2016.00189; McDonald SJ, Sun M, Agoston DV, Shultz SR. The effect of concomitant peripheral injury on traumatic brain injury pathobiology and outcome. J Neuroinflammation. 2016;13(1):90. PMID: 27117191. https://doi.org/10.1186/s12974-016-0555-1; Гребенчиков О.А., Шабанов А.К., Николаев Л.Л., Шпичко А.И., Братищев И.В., Марченко Л.Ю. и др. Влияние ксенона на провоспалительную активацию и апоптоз нейтрофилов человека в условиях ex vivo. Журнал им. Н.В. Склифосовского «Неотложная медицинская помощь». 2021;10(3):511–520. https://doi.org/10.23934/2223-90222021-10-3-511-520; Filev AD, Silachev DN, Ryzhkov IA, Lapin KN, Babkina AS, Grebenchikov OA, et al. Effect of Xenon Treatment on Gene Expression in Brain Tissue after Traumatic Brain Injury in Rats. Brain Sci. 2021; 11(7):889. PMID: 34356124. https://doi.org/10.3390/brainsci11070889.; Wilhelm S, Ma D, Maze M, Franks NP. Effects of xenon on in vitro and in vivo models of neuronal injury. Anesthesiology. 2002; 96(6):1485–1491. PMID: 12170064. https://doi.org/10.1097/00000542-200206000-00031; David HN, Leveille F, Chazalviel L, MacKenzie ET, Buisson A, Lemaire M, et al. Reduction of ischemic brain damage by nitrous oxide and xenon. J Cereb Blood Flow Metab. 2003; 23(10):1168–1173. PMID: 14526227. https://doi.org/10.1097/01.WCB.0000087342.31689.18.; Alam A, Suen KC, Hana Z, Sanders RD, Maze M, Ma D. Neuroprotection and neurotoxicity in the developing brain: an update on the effects of dexmedetomidine and xenon. Neurotoxicol Teratol. 2017; 60:102116. PMID: 28065636. https://doi.org/10.1016/j.ntt.2017.01.001. Epub 2017 Jan 6.; Höllig A, Coburn M. Noble gases and neuroprotection: summary of current evidence. Curr Opin Anaesthesiol. 2021; 34(5):603–606. PMID: 34224430. https://doi.org/10.1097/ACO.0000000000001033.; Giacino JT, Kalmar K, Whyte J. The JFK Coma Recovery Scale-Revised: measurement characteristics and diagnostic utility. Arch Phys Med Rehabil. 2004; 85(12):2020–2029. PMID: 15605342. https://doi.org/10.1016/j.apmr.2004.02.033.; Bohannon RW, Smith MB. Interrater reliability of a modified Ashworth scale of muscle spasticity. Phys Ther. 1987;67(2):206–207. PMID: 3809245. https://doi.org/10.1093/ptj/67.2.206.; Стряпко Н.В., Сазонтова Т.Г., Потиевская В.И., Хайруллина А.А., Вдовина И.Б., Куликов А.Н. и др. Адаптационный эффект многократного применения ксенона. Общая реаниматология. 2014;10(2):50–6. https://doi.org/10.15360/1813-9779-2014-2-50-56; Koziakova M, Harris K, Edge CJ, Franks NP, White IL, Dickinson R. Noble gas neuroprotection: xenon and argon protect against hypoxicischaemic injury in rat hippocampus in vitro via distinct mechanisms. Br J Anaesth. 2019;123(5):601–609. PMID: 31470983. https://doi.org/10.1016/j.bja.2019.07.010.; Höllig A, Coburn M. Noble gases and neuroprotection: summary of current evidence. Curr Opin Anaesthesiol. 2021;34(5):603–606. PMID: 34224430. https://doi.org/10.1097/ACO.0000000000001033.; Lavaur J, Lemaire M, Pype J, Le Nogue D, Hirsch EC, Michel PP. Neuroprotective and neurorestorative potential of xenon. Cell Death Dis. 2016;7(4):e2182. PMID: 27054337. https://doi.org/10.1038/cddis.2016.86.; Fahlenkamp AV, Rossaint R, Coburn M. Neuroprotektion durch Edelgase: Neue Entwicklungen und Erkenntnisse [Neuroprotection by noble gases: New developments and insights]. Anaesthesist. 2015;64(11):855– 858. (In Ger). PMID: 26329914. https://doi.org/:10.1007/s00101-0150079-6.; Azzopardi D, Robertson NJ, Kapetanakis A, Griffiths J, Rennie JM, Mathieson SR, et al. Anticonvulsant effect of xenon on neonatal asphyxial seizures. Arch Dis Child Fetal Neonatal Ed. 2013; 98(5): F437–F439. PMID: 23572341. https://doi.org/:10.1136/archdischild2013-303786.; Azzopardi D, Robertson NJ, Bainbridge A, Cady E, Charles-Edwards G, Deierl A, et al. Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBYXe): a proof-of-concept, open-label, randomised controlled trial. Lancet Neurol. 2016;15(2):145–153. PMID: 26708675. https://doi.org/10.1016/S1474-4422(15)00347-6. Epub 2015 Dec 19; Dingley J, Tooley J, Liu X, Scull-Brown E, Elstad M, Chakkarapani E, et al. Xenon ventilation during therapeutic hypothermia in neonatal encephalopathy: a feasibility study. Pediatrics. 2014;133(5):809–818. PMID: 24777219. https://doi.org/10.1542/peds.2013-0787.; Задворнов А.А., Голомидов А.В., Григорьев Е.В. Медикаментозная нейропротекция у доношенных новорожденных с тяжелой церебральной ишемией. Вестник анестезиологии и реаниматологии. 2016;13(3):51–62. https://doi.org/10.21292/2078-5658-2016-13-3-51-62; https://www.jnmp.ru/jour/article/view/1516 |
| DOI: | 10.23934/2223-9022-2022-11-4-592-599 |
| الاتاحة: | https://www.jnmp.ru/jour/article/view/1516 https://doi.org/10.23934/2223-9022-2022-11-4-592-599 |
| Rights: | Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access). ; Авторы, публикующие статьи в данном журнале, соглашаются на следующее:Авторы сохраняют за собой автороские права и предоставляют журналу право первой публикации работы, которая по истечении 6 месяцев после публикации автоматически лицензируется на условиях Creative Commons Attribution License , которая позволяет другим распространять данную работу с обязательным сохранением ссылок на авторов оригинальной работы и оригинальную публикацию в этом журнале.Авторы имеют право размещать их работу в сети Интернет (например в институтском хранилище или персональном сайте) до и во время процесса рассмотрения ее данным журналом, так как это может привести к продуктивному обсуждению и большему количеству ссылок на данную работу (См. The Effect of Open Access). |
| رقم الانضمام: | edsbas.87AA6A0E |
| قاعدة البيانات: | BASE |
| DOI: | 10.23934/2223-9022-2022-11-4-592-599 |
|---|