Academic Journal
Demonstration of differences in colonic volumes, transit, chyme consistency, and response to psyllium between healthy and constipated subjects using magnetic resonance imaging
| العنوان: | Demonstration of differences in colonic volumes, transit, chyme consistency, and response to psyllium between healthy and constipated subjects using magnetic resonance imaging |
|---|---|
| المؤلفون: | Major, G., Murray, K., Singh, G., Nowak, A., Hoad, C. L., Marciani, L., Silos‐Santiago, A., Kurtz, C. B., Johnston, J. M., Gowland, P., Spiller, R. |
| المساهمون: | National Institute for Health Research |
| المصدر: | Neurogastroenterology & Motility ; volume 30, issue 9 ; ISSN 1350-1925 1365-2982 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2018 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background In functional gastrointestinal disorders a lack of objective biomarkers limits evaluation of underlying mechanisms. We aimed to demonstrate the utility of magnetic resonance imaging for this task using psyllium, an effective constipation treatment, in patients and controls. Methods Two crossover studies: (i) adults without constipation (controls, n = 9) took three treatments in randomized order for 6 days – maltodextrin (placebo), psyllium 3.5 g t.d.s and 7 g t.d.s., (ii) adults with chronic constipation (patients, n = 20) took placebo and psyllium 7 g t.d.s. for 6 days. MRI was performed fasting and postprandially on day 6. Measurements included small bowel and ascending colon water content, colonic volume, transit time, and MR relaxometry (T1, T2) to assess colonic chyme. Stool water percentage was measured. Results 7 g psyllium t.d.s. increased fasting colonic volumes in controls from median 372 mL ( IQR 284‐601) to 578 mL ( IQR 510‐882), and in patients from median 831 mL ( IQR 745‐934) to 1104 mL (847‐1316), P < .05. Mean postprandial small bowel water was higher in controls and patients after 7 g psyllium t.d.s. vs placebo. Whole gut transit was slower in patients than controls ( P < .05). T1 of the descending colon chyme (fasting) was lower in patients (213 ms, 176‐420) than controls (440 ms, 352‐884, P < .05) on placebo, but increased by 7 g psyllium t.d.s. (590 ms, 446‐1338), P < .001. Descending colon T1 correlated with baseline stool water content and stool frequency on treatment. Conclusions and Inferences MRI measurements can objectively demonstrate the mode of action of therapy targeting intestinal fluid content in constipation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/nmo.13400 |
| الاتاحة: | http://dx.doi.org/10.1111/nmo.13400 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fnmo.13400 https://onlinelibrary.wiley.com/doi/pdf/10.1111/nmo.13400 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.87A36412 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/nmo.13400 |
|---|