Academic Journal
Mammalian Sprouty-1 and-2 Are Membrane-anchored Phosphoprotein Inhibitors of Growth Factor Signaling in Endothelial Cells
| العنوان: | Mammalian Sprouty-1 and-2 Are Membrane-anchored Phosphoprotein Inhibitors of Growth Factor Signaling in Endothelial Cells |
|---|---|
| المؤلفون: | Maria-antonietta Impagnatiello, Stefan Weitzer, Grainne Gannon, Amelia Compagni, Matt Cotten, Gerhard Christofori |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://jcb.rupress.org/content/152/5/1087.full.pdf. |
| سنة النشر: | 2001 |
| المجموعة: | CiteSeerX |
| الوصف: | Growth factor–induced signaling by receptor tyrosine kinases (RTKs) plays a central role in embryonic development and in pathogenesis and, hence, is tightly controlled by several regulatory proteins. Recently, Sprouty, an inhibitor of Drosophila development-associated RTK signaling, has been discovered. Subsequently, four mammalian Sprouty homologues (Spry-1–4) have been identified. Here, we report the functional characterization of two of them, Spry-1 and-2, in endothelial cells. Overexpressed Spry-1 and-2 inhibit fibroblast growth factor – and vascular endothelial growth factor–induced proliferation and differentiation by repressing pathways leading to p42/44 mitogen-activating protein (MAP) kinase activation. In contrast, although epidermal growth factor–induced proliferation of endothelial cells was also inhibited by Spry-1 and-2 |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.328.3467; http://jcb.rupress.org/content/152/5/1087.full.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.328.3467 http://jcb.rupress.org/content/152/5/1087.full.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.87854956 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |