التفاصيل البيبلوغرافية
| العنوان: |
Data_Sheet_1_Cognitive Impairment Impacts Exercise Effects on Cognition in Multiple Sclerosis.docx |
| المؤلفون: |
Annette Rademacher (8099639), Niklas Joisten (5939987), Sebastian Proschinger (8099636), Wilhelm Bloch (45980), Roman Gonzenbach (6639143), Jan Kool (4925167), Dawn Langdon (5367533), Jens Bansi (4028924), Philipp Zimmer (3387524) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Neurology and Neuromuscular Diseases, Neurogenetics, cognitive performance, exercise, processing speed, verbal learning, visuospatial memory, high-intensity exercise |
| الوصف: |
Purpose: Exercise training reveals high potential to beneficially impact cognitive performance in persons with multiple sclerosis (pwMS). Research indicates that high-intensity interval training (HIIT) has potentially higher effects on physical fitness and cognition compared to moderate continuous exercise. This study (i) compares the effects of a 3-week HIIT and moderate continuous exercise training on cognitive performance and cardiorespiratory fitness of pwMS in an overall analysis and (ii) investigates potential effects based on baseline cognitive status in a subgroup analysis. Methods: Seventy-five pwMS were randomly assigned to an intervention (HIIT: 5 × 1.5-min intervals at 95–100% HR max , 3 ×/week) or active control group (CG: 24 min continuous exercise at 65% HR max , 3 ×/week). Cognitive performance was assessed pre- and post-intervention with the Brief International Cognitive Assessment for MS (BICAMS). (I) To examine potential within (time) and interaction (time × group) effects in the overall analysis, separate analyses of covariance (ANCOVA) were conducted. (II) For the subgroup analysis, participants were divided into two groups [intact cognition or impaired cognition (>1.5 standard deviation (SD) compared to healthy, age-matched norm data in at least one of the three tests of the BICAMS]. Potential impacts of cognitive status and intervention were investigated with multivariate analyses of variance (MANOVA). Results: Overall analysis revealed significant time effects for processing speed, verbal learning, rel. VO2peak, and rel. power output. A time * group interaction effect was observed for rel. power output. Subgroup analysis indicated a significant main effect for cognition (impaired cognition vs. intact cognition). Subsequent post-hoc analysis showed significant larger effects on verbal learning in pwMS with impaired cognition. Conclusion: Current results need to be confirmed in a powered randomized controlled trial with cognitive performance as primary endpoint and eligibility based on ... |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/dataset/Data_Sheet_1_Cognitive_Impairment_Impacts_Exercise_Effects_on_Cognition_in_Multiple_Sclerosis_docx/13654142 |
| DOI: |
10.3389/fneur.2020.619500.s001 |
| الاتاحة: |
https://doi.org/10.3389/fneur.2020.619500.s001 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.8783ADFE |
| قاعدة البيانات: |
BASE |