Academic Journal
The polyketide MPBD initiates the SDF-1 signaling cascade that coordinates terminal differentiation in Dictyostelium.
| العنوان: | The polyketide MPBD initiates the SDF-1 signaling cascade that coordinates terminal differentiation in Dictyostelium. |
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| المؤلفون: | Anjard, Christophe, Su, Yongxuan, Loomis, William F |
| المساهمون: | Centre de génétique et de physiologie moléculaire et cellulaire (CGPhiMC), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 1535-9778. |
| بيانات النشر: | HAL CCSD American Society for Microbiology |
| سنة النشر: | 2011 |
| المجموعة: | Université de Lyon: HAL |
| مصطلحات موضوعية: | MESH: ATP-Binding Cassette Transporters, MESH: Adenylate Cyclase, MESH: Protozoan Proteins, MESH: Resorcinols, MESH: Serine Endopeptidases, MESH: Signal Transduction, MESH: Spores, Fungal, MESH: Cell Differentiation, MESH: Chemokine CXCL12, MESH: Cyclic AMP, MESH: Cyclic AMP-Dependent Protein Kinases, MESH: Dictyostelium, MESH: Morphogenesis, MESH: Mutation, MESH: Phosphopeptides, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology |
| الوصف: | International audience ; Dictyostelium uses a wide array of chemical signals to coordinate differentiation as it switches from a unicellular to a multicellular organism. MPBD, the product of the polyketide synthase encoded by stlA, regulates stalk and spore differentiation by rapidly stimulating the release of the phosphopeptide SDF-1. By analyzing specific mutants affected in MPBD or SDF-1 production, we delineated a signal transduction cascade through the membrane receptor CrlA coupled to Gα1, leading to the inhibition of GskA so that the precursor of SDF-1 is released. It is then processed by the extracellular protease of TagB on prestalk cells. SDF-1 apparently acts through the adenylyl cyclase ACG to activate the cyclic AMP (cAMP)-dependent protein kinase A (PKA) and trigger the production of more SDF-1. This signaling cascade shows similarities to the SDF-2 signaling pathway, which acts later to induce rapid spore encapsulation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/21602484; hal-00709813; https://hal.science/hal-00709813; PUBMED: 21602484; PUBMEDCENTRAL: PMC3147415 |
| DOI: | 10.1128/EC.05053-11 |
| الاتاحة: | https://hal.science/hal-00709813 https://doi.org/10.1128/EC.05053-11 |
| رقم الانضمام: | edsbas.87740A88 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/EC.05053-11 |
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