Academic Journal
Relative Information Gain: Shannon entropy-based measure of the relative structural conservation in RNA alignments
| العنوان: | Relative Information Gain: Shannon entropy-based measure of the relative structural conservation in RNA alignments |
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| المؤلفون: | Pietrosanto M., Adinolfi M., Guarracino A., Ferrè Fabrizio., Ausiello G., Vitale I., Helmer-Citterich M. |
| المساهمون: | Pietrosanto M., Adinolfi M., Guarracino A., Ferrè Fabrizio., Ausiello G., Vitale I., Helmer-Citterich M. |
| سنة النشر: | 2021 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | RNA structure, RNA comparison, RNA-protein interactions |
| الوصف: | Structural characterization of RNAs is a dynamic field, offering many modelling possibilities. RNA secondary structure models are usually characterized by an encoding that depicts structural information of the molecule through string representations or graphs. In this work, we provide a generalization of the BEAR encoding (a context-aware structural encoding we previously developed) by expanding the set of alignments used for the construction of substitution matrices and then applying it to secondary structure encodings ranging from fine-grained to more coarse-grained representations. We also introduce a re-interpretation of the Shannon Information applied on RNA alignments, proposing a new scoring metric, the Relative Information Gain (RIG). The RIG score is available for any position in an alignment, showing how different levels of detail encoded in the RNA representation can contribute differently to convey structural information. The approaches presented in this study can be used alongside state-of-the-art tools to synergistically gain insights into the structural elements that RNAs and RNA families are composed of. This additional information could potentially contribute to their improvement or increase the degree of confidence in the secondary structure of families and any set of aligned RNAs. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/33615214; info:eu-repo/semantics/altIdentifier/wos/WOS:000698594000016; volume:3; issue:1; firstpage:1; lastpage:8; numberofpages:8; journal:NAR GENOMICS AND BIOINFORMATICS; http://hdl.handle.net/11585/875931; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85110299502; https://academic.oup.com/nargab/article/3/1/lqab007/6137280 |
| DOI: | 10.1093/nargab/lqab007 |
| الاتاحة: | http://hdl.handle.net/11585/875931 https://doi.org/10.1093/nargab/lqab007 https://academic.oup.com/nargab/article/3/1/lqab007/6137280 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.87515A39 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/nargab/lqab007 |
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