Academic Journal
Detection, Treatment, and Survival of Pancreatic Cancer Recurrence in the Netherlands:A Nationwide Analysis
| العنوان: | Detection, Treatment, and Survival of Pancreatic Cancer Recurrence in the Netherlands:A Nationwide Analysis |
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| المؤلفون: | Daamen, Lois A., Groot, Vincent P., Besselink, Marc G., Bosscha, Koop, Busch, Olivier R., Cirkel, Geert A., Van Dam, Ronald M., Festen, Sebastiaan, Groot Koerkamp, Bas, Haj Mohammad, Nadia, Van Der Harst, Erwin, De Hingh, Ignace H.J.T., Intven, Martijn P.W., Kazemier, Geert, Los, Maartje, Meijer, Gert J., De Meijer, Vincent E., Nieuwenhuijs, Vincent B., Pranger, Bobby K., Raicu, Mihaela G., Schreinemakers, Jennifer M.J., Stommel, Martijn W.J., Verdonk, Robert C., Verkooijen, Helena M., Molenaar, Izaak Quintus, Van Santvoort, Hjalmar C. |
| المصدر: | Daamen , L A , Groot , V P , Besselink , M G , Bosscha , K , Busch , O R , Cirkel , G A , Van Dam , R M , Festen , S , Groot Koerkamp , B , Haj Mohammad , N , Van Der Harst , E , De Hingh , I H J T , Intven , M P W , Kazemier , G , Los , M , Meijer , G J , De Meijer , V E , Nieuwenhuijs , V B , Pranger , B K , Raicu .... |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being |
| الوصف: | Objective:To evaluate whether detection of recurrent pancreatic ductal adenocarcinoma (PDAC) in an early, asymptomatic stage increases the number of patients receiving additional treatment, subsequently improving survival.Summary of Background data:International guidelines disagree on the value of standardized postoperative surveillance for early detection and treatment of PDAC recurrence.Methods:A nationwide, observational cohort study was performed including all patients who underwent PDAC resection (2014-2016). Prospective baseline and perioperative data were retrieved from the Dutch Pancreatic Cancer Audit. Data on follow-up, treatment, and survival were collected retrospectively. Overall survival (OS) was evaluated using multivariable Cox regression analysis, before and after propensity-score matching, stratified for patients with symptomatic and asymptomatic recurrence.Results:Eight hundred thirty-six patients with a median follow-up of 37 months (interquartile range 30-48) were analyzed. Of those, 670 patients (80%) developed PDAC recurrence after a median follow-up of 10 months (interquartile range 5-17). Additional treatment was performed in 159/511 patients (31%) with symptomatic recurrence versus 77/159 (48%) asymptomatic patients (P < 0.001). After propensity-score matching on lymph node ratio, adjuvant therapy, disease-free survival, and recurrence site, additional treatment was independently associated with improved OS for both symptomatic patients [hazard ratio 0.53 (95% confidence interval 0.42-0.67); P < 0.001] and asymptomatic patients [hazard ratio 0.45 (95% confidence interval 0.29-0.70); P < 0.001].Conclusions:Additional treatment of PDAC recurrence was independently associated with improved OS, with asymptomatic patients having a higher probability to receive recurrence treatment. Therefore, standardized postoperative surveillance aiming to detect PDAC recurrence before the onset of symptoms has the potential to improve survival. This provides a rationale for prospective studies on ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1097/SLA.0000000000004093 |
| الاتاحة: | https://pure.eur.nl/en/publications/b6a08b3d-e87b-454f-9610-5423a30bf40b https://doi.org/10.1097/SLA.0000000000004093 http://www.scopus.com/inward/record.url?scp=85126072401&partnerID=8YFLogxK https://hdl.handle.net/11370/fb34b24d-00ea-4b8d-b37a-c92908db7a32 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.874B709D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/SLA.0000000000004093 |
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