Academic Journal
Synthesis, biological investigation, and in silico studies of 2-aminothiazole sulfonamide derivatives as potential antioxidants ...
| العنوان: | Synthesis, biological investigation, and in silico studies of 2-aminothiazole sulfonamide derivatives as potential antioxidants ... |
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| المؤلفون: | Worachartcheewan, Apilak, Pingaew, Ratchanok, Prachayasittikul, Veda, Apiraksattayakul, Setthawut, Prachayasittikul, Supaluk, Ruchirawat, Somsak, Prachayasittikul, Virapong |
| بيانات النشر: | IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund |
| سنة النشر: | 2025 |
| المجموعة: | DataCite Metadata Store (German National Library of Science and Technology) |
| مصطلحات موضوعية: | thiazole, sulfonamide, antioxidant, QSAR, computer-aided drug design |
| الوصف: | Antioxidant compounds have gained current interest as potential protective agents for several therapeutic applications. Antimicrobial drug resistance and infectious diseases also still be concerning globally health issues. Accordingly, the discovery of new antioxidative and antimicrobial agents is essential for human well-being. Thiazole and sulfonamide are privileged scaffolds in drug discovery due to their various bioactive properties. In this study, a series of 2-aminothiazole sulfonamide derivatives (1-12) were synthesized and investigated for their antioxidant (i.e., DPPH and SOD-mimic) and antimicrobial activities. Among tested compounds, compound 8 was the most promising one with potent DPPH and SOD (%DPPH = 90.09 %, %SOD = 99.02 %). However, none of these compounds are active antimicrobial agents. Quantitative structure-activity relationship (QSAR) modeling was performed in which the key findings were further used to guide the rational design of additional derivatives. Two antioxidant QSAR models ... : EXCLI Journal; 24:Doc60; ISSN 1611-2156 ... |
| نوع الوثيقة: | text |
| اللغة: | English |
| Relation: | https://dx.doi.org/10.17179/excli2024-7855_supplementary_information |
| DOI: | 10.17179/excli2024-7855 |
| الاتاحة: | https://dx.doi.org/10.17179/excli2024-7855 https://www.excli.de/excli/article/view/7855 |
| Rights: | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). |
| رقم الانضمام: | edsbas.8727F218 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17179/excli2024-7855 |
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